Supraclavicular Brachial Plexus Block During Upper Limb Surgeries

Status Completed

Clinical Trial Summary

Comparative Study Between Ketamine-Bupivacaine Versus Bupivacaine With Intravenous Ketamine Infusion In Supraclavicular Brachial Plexus Block During Upper limb Surgeries The techniques of regional anesthesia have become very popular as they provide several advantages in comparison with general anesthesia and systemic analgesia. They provide perfect pain control, decreased complications and reduced post-anesthesia care unit stay. Regional anesthesia provides more patient safety and better outcomes, which leads to the fact that ultrasound-guided regional anesthesia became more popular. Ultrasound provides clinicians with real-time images which are useful for better identification of the anatomical structures, safe needle placement and adequate local anesthetic spread. Brachial plexus blocks are commonly achieved via an interscalene, supraclavicular, infraclavicular or axillary approach. The supraclavicular level is an ideal site to achieve anesthesia of the entire upper extremity just distal to the shoulder as the plexus remains relatively tightly packed at this level, resulting in a rapid and high-quality block. For this reason, the supraclavicular block is often called the ''spinal of the arm'' Using the local anesthetics alone for supraclavicular brachial plexus block provide good operative conditions but have the disadvantage of shorter duration of postoperative analgesia. Various adjuvants such as opioids, dexmedetomidine, dexamethasone, midazolam, ketamine, etc., were added to local anesthetics in brachial plexus block to achieve quick and prolonged block. Ketamine is a noncompetitive antagonist of the N-methyl-D aspartate receptor(NMDAR). It is used as a premedication, and for sedation, induction and maintenance of general anesthesia. Local anesthetic and analgesic properties have been reported for ketamine. Intravenous administration of low-dose ketamine decreases postoperative opioid use and improves analgesia. Ketamine has been added to bupivacaine to prolong the duration of regional anesthesia and postoperative analgesia.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Brachial Plexus Block

Clinical Trial Details

NCT number	NCT05315271
Study type	Interventional
Source	Sohag University
Contact
Status	Completed
Phase	Early Phase 1
Start date	June 1, 2022
Completion date	January 20, 2023

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT04053491` - Comparison of the Infraclavicular and Axillary Approaches for Continuous Ultrasound-guided Brachial Plexus Block.	N/A
Completed	`NCT03211949` - Ultrasound Guided Topographic Mapping of Medial Antebrachial Cutaneous Nerve	N/A
Suspended	`NCT03291691` - Protective Nerve Stimulation in Regional Anesthesia
Completed	`NCT03270033` - Intravenous Dexmedetomidine, Dexamethasone and Interscalene Block Duration After Arthroscopic Shoulder Surgery	Phase 4
Recruiting	`NCT06015204` - Assessment of the C8 Dermatomal Block With Photoplethysmographic Amplitude After Interscalene Brachial Plexus Block	N/A
Not yet recruiting	`NCT03279679` - Comparison Between Costoclavicular and Paracoracoid Ultrasound-guided Infraclavicular Block for Forearm Surgery	N/A
Completed	`NCT02305875` - The Musculocutaneous Nerve in a High Resolution MRI	N/A
Completed	`NCT03688724` - Perioperative Diaphragm Point of Care Ultrasound
Completed	`NCT05005260` - Liposomal Bupivacaine Single-Injection Interscalene Block vs. Continuous Interscalene Block for Primary Total Shoulder Arthroplasty	Phase 4
Completed	`NCT02462408` - Conventional Versus Posterior Approach in Ultrasound-Guided Parasagittal In-Plane Infraclavicular Brachial Plexus Block	N/A
Completed	`NCT02312453` - Posterior Parasagittal In-Plane Ultrasound-Guided Infraclavicular Brachial Plexus Block	N/A
Completed	`NCT00321425` - Ultrasound Guidance Vs. Electrical Nerve Stimulation for Infraclavicular Brachial Plexus Block	N/A
Recruiting	`NCT03577860` - Ventilation and Pulmonary Aeration, Electrical Impedance Tomography, Interscalene Brachial Plexus Block	N/A
Completed	`NCT04356521` - Lateral Sagittal vs Costoclavicular Approach for Ultrasound-Guided Infraclavicular Block	N/A
Completed	`NCT04463329` - Jedi Grip vs. Double Operator Technique for Axillary Brachial Plexus Block	N/A
Not yet recruiting	`NCT04784104` - Comparison of Infraclavicular And Supraclavicular Block	Phase 4
Terminated	`NCT03785392` - Out of Plane Approach for Interscalene	N/A
Completed	`NCT02787018` - Dexamethasone Compared With Dexmedetomidine as an Adjuvant to Ropivacaine for Supraclavicular Brachial Plexus Block	Phase 3
Completed	`NCT03514342` - The Effects of Horner's Syndrome Developing After Interscalene Brachial Plexus Block on Autonomic Nervous Activity
Completed	`NCT04694105` - Peri-neural Dexmedetomidine Versus Dexamethasone for Supraaclavicular Block Adjuvant to Bupivacaine Supraclavicular Brachial Plexus Block	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.