Clinical Trials Logo

Clinical Trial Summary

The present study was designed to evaluate bowel function in preschool and early childhood in a large number of patients with anorectal Malformation and to identify the associated risk factors for bowel dysfunction.


Clinical Trial Description

Anorectal malformation (ARM) is a type of congenital malformation resulting from post-embryonic intestinal dysgenesis, occurring in about 1 in 5000 cases.Surgery is an effective means of treating ARM,which includes reconstruction of the anus and treatment of associated deformities. However, even with reconstruction of the anus, most children still have serious complications, such as constipation, fecal incontinence, urinary incontinence, and sexual dysfunction, in the mid-to-long postoperative period.A lot of studies have been designed to explore the trend toward normal bowel habits from preschool and early childhood age to adolescence or adult; however, no apparent improvement in bowel habits was completely confirmed. In contrast, many reports have shown that poor bowel function in preschool and early childhood may lead to social problems and depression in adolescence and adult.The reasons for bowel dysfunction of ARM in preschool and early childhood were complicated and undefined,including associated malformations, the type of ARM, and the development of the perianal sphincter,etc.The bowel function score (BFS) is currently used to assess mid- and long-term anal function in patients with ARM, and comprises seven major categories (e.g., self-perception, fecal control, stool collection, and social problems) with a total of 20 points, or less than 17 points, for the presence of anal weakness (11-17 points, for the general weakness, or less than 11 points, for the severe weakness) .Therefore,bowel function at preschool and early childhood should be evaluated in a large number of patients with ARM and the associated risk factors for bowel dysfunction should also be assessed. The present study was designed to evaluate bowel function in preschool and early childhood in a large number of patients with ARM and to identify the associated risk factors for bowel dysfunction using BFS. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05716230
Study type Observational
Source Nanjing Children's Hospital
Contact Changgui Lu, Dr
Phone 13770848448
Email luchanggui1984@163.com
Status Recruiting
Phase
Start date November 20, 2022
Completion date February 28, 2023

See also
  Status Clinical Trial Phase
Recruiting NCT04205058 - Coffee After Pancreatic Surgery N/A
Recruiting NCT05380856 - Sacral Neuromodulation for Neurogenic Lower Urinary Tract, Bowel and Sexual Dysfunction N/A
Completed NCT00135577 - Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects Phase 2
Completed NCT03028636 - LIBERATE - PRO: Eclipseâ„¢ System Registry
Completed NCT05880446 - PROstate CAncer Radiotherapy - Bowel Quality of Life (PROCAR-BQ) N/A
Active, not recruiting NCT06311110 - Impaired Toilet Training, LUTS and Bowel Dysfunction in Children With DCD
Not yet recruiting NCT04507945 - Stablishment of Prevention and Treatment System for Intestinal Dysfunction Phase 1/Phase 2
Completed NCT00101998 - Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication Phase 2
Completed NCT05644912 - Exploratory Investigation on a Novel Catheter N/A
Recruiting NCT04319991 - The Clinical Evaluation of Probiotics Product in Patients With Various Functional Bowel Disorders and Helicobacter Pylori Infection N/A
Completed NCT03885999 - Studies in Patients With Low Anterior Resection Syndrome (LARS) N/A
Active, not recruiting NCT04546672 - Sugammadex To IMprove Bowel Function Phase 4
Not yet recruiting NCT06252714 - Impact of Defecation Posture on Ease of Bowel Movements in Patients With a Rectocele N/A
Recruiting NCT04914975 - The Effect of NMES on Bowel Management in People With Chronic SCI N/A
Active, not recruiting NCT04490642 - Linguistic Validation of the Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) for 5-12 Years Old in Korean
Completed NCT04299867 - Perioperative Tissue Penetration of Antimicrobials in Infants
Recruiting NCT06288464 - Enteral Feeding of Fibre to Improve Microbiota N/A
Completed NCT05351138 - Comparison of Transcutaneous Electrical Nerve Stimulation and Manual Therapy in Children With Cerebral Palsy N/A
Completed NCT03841513 - Minimally Invasive Burch Colposuspension to Reduce Occult Stress Incontinence N/A
Not yet recruiting NCT03009747 - A Prospective Multi-Center Research on Bowel Dysfunction After Sphincter Preservative Surgery N/A