Bone Regeneration Clinical Trial
Official title:
Use of Xenogeneic Bone Graft Associated With Autogenous Bone Graft or Leukocyte-and-Platelet-Rich Fibrin (L-PRF) for Horizontal Bone Augmentation of Alveolar Ridge: A Randomized Controlled Clinical Trial
The objective of this randomized controlled clinical trial was to evaluate the effects of particulate xenogeneic bone grafts associated with autogenous bone graft or Leukocyte-and-Platelet-Rich Fibrin (L-PRF) for horizontal alveolar ridge augmentation. Twenty-eight patients presenting edentulous regions and requiring horizontal bone augmentation prior to dental implant placement were included in this study and randomly divided into two groups according to the proposed guided bone regeneration (GBR) treatment. Fourteen surgical sites corresponding to Group A received bone regeneration with particulate autogenous bone tissue associated with deproteinized bovine bone graft (Bio-Oss Small®; Geistlich AG, Wolhusen, Switzerland). In Group B, fourteen surgical sites were regenerated with deproteinized bovine bone graft (Bio-Oss Small®) associated with L-PRF. In both groups, the grafted region was protected by a collagen membrane (Bio-Gide® Compressed; Geistlich AG, Wolhusen, Switzerland) fixed to the buccal and palatal bone plates using titanium pins. Cone-beam computed tomography (CBCT) scans were performed preoperatively, immediately after the GBR surgical procedure, after 8 months of GBR healing, and immediately after dental implant placement to measure linear and volumetric changes in the alveolar ridge. At the time of dental implant placement, after an average period of 8 months following the guided bone regeneration procedures, bone biopsies were taken from the grafted area for histological, histomorphometric, and micro-CT analysis. After a period of 6 months, the dental implants were reopened to receive implant-supported prosthetic rehabilitation. Implant stability was assessed using resonance frequency analysis at the time of implant placement in the grafted area and after an average of 6 months during the reopening surgical stage. Patient pain perception following bone regeneration procedures was assessed using a visual analog scale. All obtained data were statistically analyzed.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05443776 -
In Vivo Investigation of 6 Membranes Including Their Physical, Chemical and Biological Properties.
|
N/A | |
Completed |
NCT04744012 -
Modified Periostal Pocket Flap Technique
|
||
Completed |
NCT03497403 -
Socket Preservation Procedure Studying Soft and Hard Tissue Outcomes
|
N/A | |
Recruiting |
NCT04149080 -
Effects of Simvastatin Gel on Bone Neoformation in Post-extraction Sockets: a Randomized Controlled Trial
|
N/A | |
Recruiting |
NCT06439264 -
Assessing the Clinical Efficacy of Bentonite Clay Gel on Bone Regeneration in the Treatment of Intra-bony Defects: A Clinico-radiograph Study
|
N/A | |
Completed |
NCT04205591 -
Comparative Study Between Porcine and Autologous Cortical Plates
|
N/A | |
Completed |
NCT03432702 -
Horizontal Ridge Augmentation With or Without Autogenous Block Grafts
|
N/A | |
Terminated |
NCT02387008 -
Prospective, Comparative Assessment of Alveolar Bone Augmentation Using GUIDOR® Membrane in the Bound Edentulous Space
|
N/A | |
Recruiting |
NCT04937023 -
Ursodeoxycholic Acid (Udca) as a Local Drug Delivery Agent in the Treatment of Intra-bony Defects
|
N/A | |
Completed |
NCT05791123 -
Alveolar Ridge Augmentation Following Tooth Extraction Using Bovine Xenograft With Platelet Rich Fibrin Membrane
|
N/A | |
Recruiting |
NCT06168500 -
Narrow Implants Vs Standard Implants With Simultaneous GBR
|
N/A | |
Terminated |
NCT00435877 -
Procurement of Tissue Samples for Cell Cultures and Analyses
|
||
Completed |
NCT03391258 -
Guided Bone Regeneration With L-PRF in the Atrophic Maxilla - The GLAM Technique
|
N/A | |
Completed |
NCT03496688 -
Comparative Results of Six Biomaterials Used in Two-stage Maxillary Sinus
|
N/A | |
Active, not recruiting |
NCT04338139 -
Influence of Bio-Oss Collagen Grafting at Implant Placement on Buccal Bone Volume Regeneration
|
N/A | |
Active, not recruiting |
NCT06226116 -
COMPARATIVE STUDY OF BONE IMPLANT CONTACT (BIC) ON NEW BONE REGENERATED WITH AUTOGENOUS DENTIN AND NATIVE BONE
|
N/A | |
Completed |
NCT04131894 -
Effects of Autogenous Dentin Graft on Socket Preservation
|
Phase 4 | |
Recruiting |
NCT06061354 -
Teriparatide on Maxillary Sinus Floor Osseointegration
|
Phase 4 | |
Completed |
NCT03785717 -
Horizontal Ridge Augmentation in Mandible Usign ROG + ESWT
|
N/A | |
Completed |
NCT02890680 -
Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery
|
N/A |