Bone Neoplasms Clinical Trial
Official title:
Malignant Pediatric Soft Tissue & Bone Tumors of the Extremities: A Retrospective Study
The aim of this study is to identify demographic & disease characteristics in pediatric oncology patients diagnosed with soft tissue & bone tumors involving the extremities & treatment outcomes in these patients.
Background:
Sarcomas are a heterogeneous group of rare tumors that arise predominantly from the embryonic
mesoderm. The various sarcomas include bone sarcomas (osteosarcomas and chondrosarcomas),
Ewing's sarcomas, peripheral primitive neuroectodermal tumors, and soft tissue sarcomas.
Soft tissue sarcomas account for approximately 1% of adult malignancies and 7% to 15% of
pediatric malignancies. Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood.
There is some confusion within segments of the medical community as to the precise meaning of
"soft tissue." The soft tissue of the human body includes all extraskeletal tissue that is
neither epithelial, hematopoietic (marrow derived blood elements), nor parenchymal
(constituent of a visceral organ). The nervous system is divided such that neither the glial
nor the central neuronal elements are considered to be soft tissue, though by convention the
peripheral nervous system is. In sum, the soft tissues consist of adipose tissue, fibrous
tissue, musculature, vascular structures, and peripheral nerves.
About 50% to 60% of sarcomas occur in the extremities, and although they are rare, they are
responsible for more deaths than testicular cancer, Hodgkin's disease, and thyroid cancer
combined.
Patients & Methods:
From January 2000 till December 2015, retrieval & analysis of the medical records of
pediatric patients with soft tissue & bone tumors involving the extremities will be made at
the pediatric oncology department, South Egypt Cancer Institute which represents the largest
referral center in Upper Egypt. These data will be categorized according to demographic
characteristics, clinico-pathologic features, treatment modalities received, and outcomes of
treatments in these patients.
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