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Bone Quality by vQCT and HR-pQCT:Translation to Multi-center Clinical Research — Interscanner  

Bone Mineral Density Clinical Trial

Official title:
Bone Quality by vQCT and HR-pQCT:Translation to Multi-center Clinical Research

Clinical Trial Summary

Our overarching aim is to set up a procedural, analytic and developmental framework to establish CT of the central and peripheral skeleton as a clinically useful biomarker for skeletal strength in the clinical research and ultimately in the clinical setting. To accomplish this, the investigators will develop and validate phantoms and scanning procedures to standardize strength and structure measurements between different vQCT scanners and develop standardized acquisition, analytical, and quality control techniques for HR-pQCT with an emphasis on optimization for multi-center studies.

Clinical Trial Description

The investigators will develop new calibration phantoms to address inter and intra scanner variability in vQCT and HRpQCT. Phantom sets to evaluate inter-scanner disparity and determine corrections to apply to in vivo scan data in the multi-center settings. These methods will be validated in a multi-center phantom study and in a 120 patients ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01544660
Study type Observational
Source University of California, San Francisco
Contact
Status Completed
Phase N/A
Start date April 2012
Completion date March 2014
View Details
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