Bone Metastases Clinical Trial
Official title:
Evaluation of an Accelerated Body-whole Bone CT Procedure With the CZT "VERITON-CT ™" Camera: a Comparison With the Conventional Full-body 2D Recording Procedure With or Without Complementary Tomoscintigraphy.
The purpose of the OSS study is to evaluate a procedure involving a single full body TEMP / TDM 3D recording with a new semiconductor camera, the VERITON-CT ™ (Spectrum Dynamics Medical). This recording can be done in less than 25 minutes due to an original system of CZT (Cadmium-Zinc-Telluride) detectors allowing to increase the quality of the images and especially, to multiply by a factor 2 to 3 the detection sensitivity. This camera is also equipped with a scanner capable of obtaining a body-to-integer recording with a low level of irradiation (≤ 2 mSv)
Interventional study (RIPH-2), monocentric and randomized in open. All patients routinely
referred for bone scans as part of a search for primary or metastatic neoplastic bone lesions
(known neoplastic history) will be offered to participate in the study by the doctors of the
nuclear medicine department of the CHRU from Nancy.
The capture of tracers used for bone scintigraphy (technetium-99m-labeled bisphosphonates) is
highly dependent on bone remodeling, osteoblast activity and tissue perfusion . This is why
bone scintigraphy is a sensitive examination, capable of detecting anomalies before their
radiological translation . 3-dimensional (3D) recordings called SPECT detect bone metastases
with a sensitivity equivalent to that of MRI .
These SPECT are most often produced by hybrid systems, in combination with X-ray scanner (CT)
recordings, which makes it possible to correct certain imperfections in the quantification of
the measured activities (attenuation, diffusion, partial volume) and also, to complete the
characterization of lesions.
Bone diseases, which are often diffuse, frequently require two-dimensional (2D) whole body
recordings, but these are unfortunately less informative and less sensitive than 3D
recordings. This is why complementary focused SPECT / CT images are recommended for areas
that are difficult to explore, especially the pelvis and spine, and when neoplastic lesions
are suspected. This registration procedure is long (about 40 minutes), difficult for some
patients to support, and does not offer an optimal 3D analysis of the entire skeleton.
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