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Study of the Role of the Induced Membrane in the Reconstruction of Bone Loss in the Limbs — MEMBRAN  

Bone Loss Clinical Trial

Official title:
Study of the Role of the Induced Membrane in the Reconstruction of Bone Loss in the Limbs

Clinical Trial Summary

Masquelet's induced membrane technique is a two-stage reconstructive surgery for severe bone fractures commonly used by military orthopedists. The particularity of this technique relies on the synthesis of a biological membrane induced by the transient implantation of a surgical cement (= 1st stage surgery). The presence of the induced membrane in the reconstruction space defines a microenvironment or "biological chamber" favourable to osteogenesis, positively influencing the repair of the lesion after implantation of an autologous bone graft (= 2nd stage of surgery). In view of the excellent clinical results obtained with this procedure, the Masquelet technique has gradually become a reference treatment in the field of orthopedic and trauma surgery. However, orthopedic surgeons sometimes observe failures in bone consolidation. To our knowledge, the role played by induced membrane in these therapeutic failures has never been studied.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04883502
Study type Observational
Source Direction Centrale du Service de Santé des Armées
Contact Marjorie DURAND, PhD
Phone 178651146
Email marjorie1.durand@intradef.gouv.fr
Status Recruiting
Phase
Start date October 29, 2021
Completion date April 2028
View Details
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