The Associations Between Sedentary Behaviour and Impact Characteristics on Bone Health

Bone Health Clinical Trial

Official title:

The Associations Between Sedentary Behaviour and Impact Characteristics on Bone Health

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02928913
• Other study ID #: 01/0416/TS/UOW
• Status: Completed
• Phase: N/A
• First received: October 5, 2016
• Last updated: October 25, 2017
• Start date: May 2016
• Est. completion date: July 2017

Study information

• Verified date: October 2017
• Source: University of Wolverhampton
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To investigate associations between sedentary and active behaviour with bone health and functional ability, and to associate mechanical loading at the lumbar spine and hip in sedentary and active individuals with bone mineral density.

Description:

Significant proportions of adults engage in sedentary behaviour for prolonged periods of time which is generally regarded as having deleterious effects on health. However, far less is known about its specific effects on bone health. Exercise has been proposed as a method of improving bone health, as impact forces generated as the foot contacts the ground during physical activity have the potential to aid bone maintenance and development.

The properties of bone are regulated through the amount mechanical loading, frequency of loading and duration of loading endured, which can create an osteogenic effect. These variables can be quantified via accelerometry which records the magnitude, rate and duration of accelerations experienced at the site on the body where the accelerometer is worn. Although there is a vast amount of literature where accelerometers have been used to monitor physical activity, there is a lack of studies that use accelerometers to determine the most effective exercise for bone, especially in relation to the lumbar spine. Exploring the bone health and loading characteristics of sedentary and low and highly active non-sedentary individuals will provide evidence upon which to base future interventions that are likely to be of benefit for bone health in sedentary populations.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 56
• Est. completion date: July 2017
• Est. primary completion date: July 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 30 Years to 60 Years

Eligibility

Inclusion Criteria:

Male or female aged 30 - 60 years Individuals who are sedentary and do not participate in physical activities Individuals who participate in some physical activities Individuals who are highly active Must be free from injury or illness that will affects following typical weekly routines.

Exclusion Criteria:

Any medical condition that affects bone health, e.g. osteoporosis. Currently takes medication that affects bone health, e.g. long term steroid use.

Inability to participate in typical daily activity, e.g. severe arthritis, injury. Women who are post menopause Women who are on hormone replacement therapy Unable to participate in DXA scan, e.g. due to recent exposure to radiation, pregnancy status.

Related Conditions & MeSH terms

• Bone Health

Intervention

Other:
• No intervention

Locations

Country	Name	City	State
United Kingdom	University of Wolverhampton	Walsall	West Midlands

Sponsors (2)

Lead Sponsor	Collaborator
Dr Tina Smith	London South Bank University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Bone mineral density		One day
Secondary	Mechanical loading dose during daily activity via accelerometry		7 days
Secondary	Mechanical loading intensity during daily activity via accelerometry		7 days
Secondary	Functional movement assessment: Grip Strength		One day
Secondary	Functional movement assessment: Timed up and go		One day
Secondary	Functional movement assessment: 10m walk test		One day
Secondary	Functional movement assessment: 5 times sit to stand		One day
Secondary	Functional movement assessment: gait analysis (acceleration at hip and lumbar spine)		One day
Secondary	Functional movement assessment: gait analysis (ground reaction force)		One day