Bone Cyst Clinical Trial
Official title:
Effect of Bone Marrow-derived Mesenchymal Stem Cell Transplantation in Reconstructing Bone Defects.
There are two types of bone cysts, unicameral and aneurismal. These cysts happen to anyone,
but they are most commonly seen in children and young adults while their bones are still
growing. Living with a bone cyst and determining treatment options depend on the type of
cyst.
Non-surgical treatments for unicameral bone cysts involves repeated X-rays in individuals
who do not experience any symptoms.
Surgical removal of a unicameral bone cyst is needed if it becomes especially painful, or
the area of the bone starts to thin out. The investigators aim to assess the clinical
efficacy and side effects of mesenchymal stem cells seeded on bone matrix in repairing bone
cyst.
Bone cysts are benign lesions usually discovered in children from age of 5 to 15 years. Treatment options include observation, corticosteroid injection and surgery. Sometimes the risk of surgery is comparable to the likelihood of fracture without treatment. In orthopedic surgery, bone chips , various types of ceramics, natural and synthetized bone mineral hydroxyapatite and tricalcium phosphate, as well as numerous polymers and co-polymers of alfa-hydroxy acids are used to perform as an osteoconductive and rarely osteoinductive factor to help bone formation.Some evidence demonstrated that bone marrow mesenchymal stem cells deposited on the surface of this constructs enhance its osteogenic differentiation. In this study the investigators seeds cultured bone marrow derived mesenchymal stem cells on bone matrix, to evaluate its therapeutic potential in repairing unicameral or aneurysmal bone cyst.This composite is placed in the bone cyst after its curettage during a surgery.Post-operation assessment is done by X-Ray examination and MRI at 1, 2, 6, and 12 months after treatment. ;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT02575352 -
Calcium Phosphate Cement Registry (CPC Registry)
|
||
| Recruiting |
NCT02193841 -
Simple Bone Cysts in Kids
|
Phase 3 | |
| Completed |
NCT02567084 -
Complete Twelve Month Bone Remodeling With a Bi-phasic Injectable Bone Substitute in Benign Bone Tumors
|
N/A |