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Clinical Trial Summary

The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI). However, the tolerability of such high-dose intravenous regimens is poorly known. T


Clinical Trial Description

The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI). However, the tolerability of such high-dose intravenous regimens is poorly known. The empirical antimicrobial therapy of PJI is associated with an important rate of adverse, linked with the use of the vancomycin and the piperacillin-tazobactam combination. Some studies suggest to use vancomycin-cefepime, which remains to be evaluated in PJI. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03850860
Study type Observational
Source Hospices Civils de Lyon
Contact
Status Completed
Phase
Start date December 1, 2018
Completion date June 1, 2019

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