Body Composition Clinical Trial
Official title:
Body Composition and Adipose Tissue in HIV Lipodystrophy: Effects of Tesamorelin Therapy
In this study, the investigators will examine the effect of therapy with the Growth Hormone Releasing Hormone (GHRH) analog tesamorelin on body composition in patients with HIV lipodystrophy and central adiposity. This study is a single arm prospective study of tesamorelin therapy of patients with HIV lipodystrophy. Subjects will do body composition testing, adipose tissue biopsy, metabolic rate measurements and insulin sensitivity assessment before, 6 and 12 months after daily injections of tesamorelin 2 mg by subcutaneous injection.
HIV lipodystrophy is increasingly recognized as a common and clinically significant long-term sequelae of HIV treatment. In the HIV lipodystrophy lipohypertrophy phenotype, visceral adipose tissue (VAT) is increased and this is associated with reduced growth hormone (GH) secretion. Mounting evidence also links this phenotype with dyslipidemia, insulin resistance, subclinical atherosclerosis and cardiovascular (CV) disease in patients with HIV disease. The etiology of HIV lipodystrophy (HIVLD) with central adiposity is unclear, but this phenotype is increasingly common with newer, less lipotoxic combination anti-retroviral therapy (cART) use. VAT and hepatic lipid accumulation, are important health concerns for HIVLD patients. This body composition pattern may contribute to the increased cardiovascular risk that has been demonstrated in patients with HIV lipodystrophy. Patients with HIVLD and central adiposity have been shown to have reduced GH secretion. Thus, a medication has been developed to augment GH secretion. This medication is tesamorelin. GH supplementation in other clinical settings has been shown to reduce visceral adiposity and may reduce hepatic lipid content. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT05512559 -
Body Composition Analysis and Time to Emergence From Remimazolam
|
||
| Enrolling by invitation |
NCT05515835 -
Relationship Between Effect Duration of Rocuronium and Body Composition Analysis Data.
|
||
| Completed |
NCT04136821 -
The Long-term Effects of Oceanix™ on Resistance Training Adaptations
|
N/A | |
| Completed |
NCT03432130 -
Injury Occurrence in Hip-hop Dance
|
N/A | |
| Completed |
NCT04504799 -
Validation of the New HAG-B19 Scale for Measuring Lean and Fat Body Masse
|
||
| Withdrawn |
NCT04021446 -
A Supervised Clinic-to-Community Exercise Intervention to Improve Cardiometabolic Health in Survivors of AYA Cancer
|
N/A | |
| Completed |
NCT03412578 -
Effect of Tactile/Kinaesthetic Massage Therapy on DXA Parameter of Preterm Infants
|
N/A | |
| Completed |
NCT02211612 -
Overeating Different Fats and Influence on Muscle Mass and Body Fat Accumulation
|
N/A | |
| Completed |
NCT02000492 -
Frequent Ballgames Training for 9-11 Year Old Schoolchildren
|
N/A | |
| Completed |
NCT01209936 -
Hydration Factor Study for the Stayhealthy BC3
|
N/A | |
| Recruiting |
NCT06061315 -
Effect of Collagen Peptides, in Combination With Resistance Training, on Body Composition and Muscle Strength in Untrained Men
|
N/A | |
| Completed |
NCT05730660 -
Quercetin Phytosome® Chronic Fatigue Syndrome
|
N/A | |
| Recruiting |
NCT04969588 -
Kinect Equations for Body Indices and Body Composition
|
||
| Completed |
NCT04828655 -
Analysis of Bioparametric Measures for Correlating Daily Habits and Reducing Blood Pressure
|
N/A | |
| Completed |
NCT04404413 -
High-Intensity Interval Training and Intermittent Fasting on Body Composition and Physical Performance in Active Women
|
N/A | |
| Completed |
NCT05052164 -
Improvement Of Physical And Physiological Parameters In Menopausal Or Post-Menopausal Celiac Women
|
N/A | |
| Completed |
NCT03352583 -
Effects of Casein Timing on Body Composition and Performance
|
N/A | |
| Enrolling by invitation |
NCT03587233 -
Are Women With Higher Professional Status More Sedentary Compared to Men?
|
N/A | |
| Recruiting |
NCT05556239 -
STAY-STRONG Study of Exercise Training During Chemotherapy
|
N/A | |
| Active, not recruiting |
NCT04306523 -
Early Genetic and Environmental Influences on Eating - The Baylor Infant Twins Study
|