The Effect of PXR Activation on Blood Pressure Regulation

Blood Pressure Regulation Clinical Trial

Official title: The Effect of PXR Activation on Blood Pressure Regulation

Status Completed

Clinical Trial Summary

We are investigating the effects of pregnane X receptor (PXR) activation on the regulation of blood pressure in healthy volunteers. Rifampicin (an antibiotic and also an efficient PXR activator) and placebo will be given for a week to volunteers and blood pressure is measured 24 hours using an ambulatory blood pressure monitor. Blood pressure regulating hormones will be measured in blood. Our hypothesis is that PXR is involved in the regulation of blood pressure.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Blood Pressure Regulation

• NCT number: NCT01690104
• Study type: Interventional
• Source: University of Oulu
• Status: Completed
• Phase: Phase 4
• Start date: August 2012
• Completion date: December 2013