Effect of Low Tidal Volume on Blood Loss During Laparoscopic Hepatectomy

Blood Loss Clinical Trial

Official title:

Effect of Low Tidal Volume on Blood Loss During Laparoscopic Hepatectomy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03399123
• Other study ID #: MZK001
• Status: Recruiting
• Phase: N/A
• First received: January 4, 2018
• Last updated: January 11, 2018
• Start date: April 1, 2017
• Est. completion date: October 30, 2018

Study information

• Verified date: January 2018
• Source: Southwest Hospital, China
• Contact: Ning Jiaolin
• Phone: 0086-15808014085
• Email: Njiaolin1976[@]126.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy

Description:

Background & Aims:Liver cancer is an disease that threatening human health .Laparoscopic hepatectomy is more and more widely used.It is very important to reduce the bleeding during laparoscopic hepatectomy.The investigators found that low tidal volume can effectively reduce intraoperative bleeding.The aim of this study was to explore the effect of low tidal volume on blood loss and gas exchange during laparoscopic hepatectomy

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 104
• Est. completion date: October 30, 2018
• Est. primary completion date: October 30, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 70 Years

Eligibility

Inclusion Criteria:

1. Aged from 18 to 70 years old;

2. American association of anesthesiologists(ASA) score I to III;

3. Ability to adhere to the study schedule;

4. Ability to provide informed consent and complete all study assessments;

5. Patients undergoing selective surgery of laparoscopic hepatectomy.

Exclusion Criteria:

1. The New York Heart Association classification(NYHA) III to IV;

2. Chronic obstructive pulmonary disease,respiratory failure, patients after thoracic surgery.

3. BMI>32Kg/m2;

4. Abnormal in blood coagulation function;

5. Patients with mental disease;

6. Patients with neuromuscular disease;

7. Concurrent enrollment in another Randomized controlled trial(RCT);

8. Absence of written informed consent.

Related Conditions & MeSH terms

• Blood Loss
• Hemorrhage

Intervention

Other:
• Tidal volume
After General anesthesia, patients that during volume control mode of mechanical ventilation in experimental group, we take low tidal volume.

Locations

Country	Name	City	State
China	Southwest Hospital	Chongqing	Chongqing

Sponsors (1)

Lead Sponsor	Collaborator
Southwest Hospital, China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood loss	Blood loss during operation.	through study completion, an average of 48hours
Secondary	central venous pressure	The central venous pressure(CVP)during operation	During operation
Secondary	mean arterial pressure	The mean arterial pressure(MAP)during operation	During operation
Secondary	oxygenation index	The oxygenation index during operation.	During operation