Blood Iron Isotope Enrichment Clinical Trial
Official title:
A Stable Iron Isotope Study to Investigate the Impact of Phytic Acid and Polyphenols on Iron Absorption From Beans in Humans
Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have
the potential to alleviate iron bioavailability problems associated with PA. These plants
have normal phosphate levels, but reduced PA phosphate due to various modifications of the
biosynthetic pathway of PA. So far lpa crops are in an early stage of development, most of
them exhibiting reduced yield and seed germination. However, the lpa bean isolated by
Campion and co-workers 2009 by chemical mutagenesis exhibited only 10 % of the native bean
PA concentration without any defects in terms of growth and yield.
Crossing the lpa variety with bean varieties low in PP and high in iron might lead to the
development of a variety which has the potential to improve the iron status of bean
consuming populations.
The following study will evaluate the relative impact of PA and PP on iron absorption from
beans by comparing iron absorption from four different bean varieties. Iron absorption from
a bean with normal PA concentration and high PP concentration will be compared to iron
absorption from a bean with normal PA and low PP concentration as well as to two lpa
varieties, one with high and one with low PP concentration.
n/a
Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science