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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05319951
Other study ID # Different liquids intake
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 20, 2021
Est. completion date December 31, 2021

Study information

Verified date September 2022
Source Guangzhou Blood Center
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

we compared the effect of 3 different kinds of liquids (water, Oral Rehydration Salt 3 and white granulated sugar water) intake in Vasovagal Reaction After Whole Blood Donation


Description:

Vasovagal reaction is the most common type of blood donation reaction. The main cause of this reaction is the decrease of blood volume. Therefore, fluid supplement before blood donation has been proved to be effective in preventing the vagal reaction after blood donation. It was proved that isotonic (sugar & salt) drink intake before blood donation had a significant effect on reducing vasovagal reaction. However, in 2002, WHO recommended the new reduced osmolarity rehydration formula with better taste. Oral Rehydration Salt 3 has been produced according to WHO formula with standard ingredient and easy to prepare. In addition, in Guangdong culture, sugar water is regarded as a tonic, more easily accepted. So, the aim of our study was to compare the effects of 500 ml water with Oral Rehydration Salt 3, white granulated sugar and conventional recommended water intake prior to blood donation on blood donation reaction after whole blood donation, in order to understand the effect of different liquid supplement on blood donation reaction and the willingness of blood donation again.


Recruitment information / eligibility

Status Completed
Enrollment 6250
Est. completion date December 31, 2021
Est. primary completion date November 26, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:All blood donors donated whole blood in Guangzhou Blood Center during study. - Exclusion Criteria:Blood donors who were deferral by blood screening result and other situations. -

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Oral Rehydration Salts power (iii)
Dissolve 2 packs of Oral Rehydration Salts Power (iii) (5.125g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.
Dietary Supplement:
water with white granulated sugar
Dissolve 2 packs of Taikoo white granulated sugar (5g/pack) in 500ml water and let the subjects drink it up in 20 minutes prior to donation.
water
Recommend the subjects to drink up 500ml water in 20 minutes prior to donation.

Locations

Country Name City State
China Guangzhou Blood Center Guangzhou Guangdong

Sponsors (1)

Lead Sponsor Collaborator
Guangzhou Blood Center

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary vasovagal reaction rate vasovagal reaction rate in three groups 1-3days
Secondary rate of willingness to donate blood again rate of willingness to donate blood again in three groups 3days
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