Blood Disorders Clinical Trial
Official title:
Prospective Observational Study of Fecal Microbiota Transplantation Used to Eradicate Gut-colonizing Multidrug-resistant Bacteria in Patients With Blood Disorders
During this prospective observational study, the investigators collect the information about
the outcomes of fecal microbiota transplantation in patients with blood disorders, performed
to eradicate gut colonization with multidrug-resistant (MDR) bacteria.
Patients with blood disorders are characterized by poor diversity of gut microbiome,
affected by repeated chemotherapy and antimicrobial treatments. This makes them vulnerable
to colonization by pathogenic bacteria carrying genes responsible for antibiotic resistance.
In case of gut mucosa injury and severe immune suppression, these colonizing bacteria may
cause severe systemic infections. As the bacteria are secreted with the stool, the colonized
patients become an epidemiologic threat to the others.
Fecal microbiota transplantation (FMT) was shown to be very efficient in treatment of
relapsed and refractory Clostridium difficile infection and became a standard treatment. In
home institution, the investigators use FMT not only in case of Clostridium difficile
colitis, but also in case of gut colonization with multidrug-resistant (MDR) bacteria. This
is based on assumption that physiological gut flora may outcompete the pathogenic bacteria
similarly as in case of Clostridium difficile and lead to loss of colonization. The
procedure is performed in all patients colonized, who qualify according to listed inclusion
and exclusion criteria .
n/a
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT02218151 -
Medical Home Care for Hematopoietic Stem Cell Transplantation Phase 2
|
N/A | |
| Completed |
NCT02095951 -
Preemptive Ethanol Lock Therapy in Pediatric Bloodstream Infection
|
Phase 4 |