Blood Disease Clinical Trial
To identify factors that affected the National Marrow Donor Program's (NMDP) success in retention of bone marrow volunteers.
BACKGROUND:
As bone marrow transplantation becomes one of the preferred treatments for life-threatening
diseases of the blood, increasing numbers of patients must seek compatible marrow from
unrelated donors. The low probability of finding a good patient-donor marrow match means
that between one- to two-thirds of ill patients never locate a donor with perfectly
compatible marrow. Furthermore, once volunteers are identified as a preliminary match for a
patient, 30 to 40 percent are either unwilling or medically unable to actually donate
marrow. Thus, volunteer attrition contributes significantly to the problems already inherent
in finding a suitable donor candidate.
DESIGN NARRATIVE:
The study examined the relationship of volunteer characteristics and donor center factors to
volunteer psychological outcomes during two critical stages in the blood testing process and
to donor center rates of volunteer cooperation at these stages.
Longitudinal and cross-sectional survey data were gathered from a total of over 2,900
potential marrow donors who were at one of two critical decision points in the process
leading to donation (DR-blood-typing, CT-blood-typing), and from personnel at the 100 NMDP
donor centers. These data allowed the investigators to (a) describe the distribution and
interrelationships between donor center structural characteristics and the strategies
centers utilize for volunteer recruitment and retention, (b) determine which donor center
factors (both structural and tactical) and volunteer background characteristics best predict
positive volunteer-specific psychological outcomes at later typing stages, and examine and
revise models of individual volunteer-specific outcomes and aggregate across-center
retention rates.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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