Blood Coagulation Disorders Clinical Trial
Official title:
A Prospective Study of Airless Tubing in an Inpatient Acute Hemodialysis Unit in Hospitalized Patients in a Large Medical Center
The introduction of unfractionated heparin (UFH), which prevents clotting of the
extracorporal circuit, was one of the key advances that led to the rapid development and
expansion of hemodialysis services. However, anticoagulation during hemodialysis of the
patient at high risk for bleeding remains a frequently encountered problem in both inpatient
and outpatient dialysis practice.
Streamline bloodlines are designed to eliminate blood-air contact. This is thought to help
reduce heparin use and decrease clotting rates. The goal of this study was to prospectively
examine impact of the Streamline airless blood tubing set, in an inpatient setting, on
dialysis circuit clotting rates, anticoagulation use, and dialysis efficiency.
The introduction of unfractionated heparin (UFH), which prevents clotting of the
extracorporeal circuit, was one of the key advances that led to the rapid development and
expansion of hemodialysis use, and remains the mainstay in hemodialysis practice today.
However, anticoagulation during hemodialysis of the patient at high risk for bleeding remains
a frequently encountered problem in the nephrology practice. The need for anticoagulation to
prevent clotting of the extracorporeal blood circuit and the need to prevent anticoagulation
related bleeding complications in the patient has led to the development of numerous
strategies; the safest from a bleeding standpoint being anticoagulant-free hemodialysis.
Streamline® bloodlines (Medisystems® Corporation, Lawrence, MA) are designed to eliminate
blood-air contact. A pressure pod measures arterial and venous pressures without any
blood-air contact. The venous chamber is run without an air gap. It is also designed so that
blood flows in a circular vortex manner. This airless system is thought to provide several
benefits: improved dialysis efficiency and blood flow rates, reduced heparin use and clotting
rates.
The goal of this study was to prospectively examine the Streamline® airless tubing system in
an inpatient setting and its association with clotting rates, and dialysis efficiency.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT02239991 -
Management of Perioperative Coagulopathy With Thromboelastometry (ROTEM) in Liver Transplant
|
N/A | |
Completed |
NCT01435304 -
The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass
|
N/A | |
Completed |
NCT00969319 -
Effekt-2 - Efficacy and Safety of Long-term Treatment With KOGENATE® FS in Latin America
|
N/A | |
Completed |
NCT00091494 -
Socioeconomic Patterning of Inflammation and Hemostasis - Ancillary to MESA
|
N/A | |
Completed |
NCT00005481 -
Epidemiology of Impaired Coagulant Balance in Diabetes
|
N/A | |
Recruiting |
NCT02379104 -
ROTEM® Sigma Performance Evaluation - Method Comparison With Predicate Device and Reference Intervals
|
N/A | |
Withdrawn |
NCT02774317 -
Pilot Study to Compare Fresh Frozen Plasma With 24-Hour Plasma in Babies Up to Age Six Months
|
Phase 4 | |
Recruiting |
NCT01930916 -
Accuracy of a Portable International Normalized Ratio Monitor in Elderly Patients
|
N/A | |
Completed |
NCT00168090 -
Study of Safety and Efficacy of Antihemophilic Factor/Von Willebrand Factor Complex in Surgical Subjects With Von Willebrand Disease (vWD)
|
Phase 4 | |
Completed |
NCT01787552 -
A Phase Ib/II Dose-finding Study to Assess the Safety and Efficacy of LDE225 + INC424 in Patients With MF
|
Phase 1/Phase 2 | |
Not yet recruiting |
NCT02782338 -
The Effect of Voltaren-ophtha 0.1% Eye Drops on INR Levels (International Normalized Ratio) in Patients Taking Warfarin
|
N/A | |
Unknown status |
NCT01349712 -
Study to Test the Accuracy of a Prototype Handheld PT/INR Device
|
N/A | |
Completed |
NCT01143909 -
Transfusion of Fresh Frozen Plasma in Non-bleeding Intensive Care Unit (ICU) Patients
|
N/A | |
Recruiting |
NCT04762550 -
Thrombin Generation in Liver Transplant Surgery
|
||
Withdrawn |
NCT01221389 -
Study Using Plasma for Patients Requiring Emergency Surgery
|
Phase 4 | |
Withdrawn |
NCT00233246 -
Fresh-Frozen Plasma Infusions to Reduce Risk of Bleeding Related to Invasive Procedures
|
Phase 3 | |
Recruiting |
NCT03884725 -
Fibrinogen Concentrate In Children Cardiac Surgery 2
|
Phase 4 | |
Completed |
NCT00086476 -
Study of Megakaryocytes From Patients With Abnormal Platelet Vesicles
|
N/A | |
Completed |
NCT00516126 -
Goal-orientated Therapy of Perioperative Disturbance in Hemostasis in Cardiac Surgery
|
Phase 4 | |
Completed |
NCT00708435 -
Efficacy and Safety Study of BERIPLEX® P/N (Kcentra) Compared With Plasma in Patients With Acute Major Bleeding Caused by Anticoagulant Therapy
|
Phase 3 |