Clinical Trials Logo
  1. Home
  2. Blood Coagulation Disorder
  3. NCT06174961

The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin

Blood Coagulation Disorder Clinical Trial

Official title:
The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin: A Randomized, Controlled, Cross-over Study

Clinical Trial Summary

The aim of this project is to assess the influence of exercise on pharmacokinetics (PK) and pharmacodynamics (PD) of a single dose of subcutaneously (sc) administered unfractionated heparin (UFH). It is hypothesized that exercise will increase the systemic exposure (PK) and therefore the clinical effects (PD) of the sc administered UFH. To assess this, healthy male volunteers will be included in a controlled, randomized, crossover study, where they, on four separate days, will have UFH injected sc in the thigh, followed by different exercise interventions (one per experimental day). Blood sampling, with the aim of assessing PK and PD will be performed during the following hours.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06174961
Study type Interventional
Source University Hospital Bispebjerg and Frederiksberg
Contact
Status Active, not recruiting
Phase Phase 4
Start date September 22, 2023
Completion date January 31, 2025
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04499274 - Ondansetron and Blood Coagulation N/A
Recruiting NCT04507711 - Palonosetron and Blood Coagulation N/A
Recruiting NCT06403163 - Transfusion Surveillance in Anaesthesia
Terminated NCT00288808 - Comparison Between Point of Care Device and Venous Blood International Normalized Ratio Measurements. Phase 1
Completed NCT03666650 - NOAC Plasma Concentration and Blood Coagulation in Healthy Volunteers Phase 4
Recruiting NCT04896203 - Hypercoagulability Study Using Haemostatic Techniques in Patients With Inflammatory Bowel Disease
Completed NCT03821597 - Sequential Compression Devices Effect on Fibrinolysis in Plastic Surgery Outpatients N/A
Completed NCT03168087 - Plasmalyte-148 Solution and Blood Coagulation
Not yet recruiting NCT05698160 - Biomarkers and Prediction of Tigecycline Induced Coagulation Dysfunction
Completed NCT02387944 - Bedside Evaluation of Coagulation in Children With Congenital Heart Disease N/A
Completed NCT03105180 - Irrigating Fluid and Blood Coagulation N/A
Recruiting NCT03255928 - Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)
Completed NCT02601053 - The Fear F8ctor Study - Does Fear Induce a Blood Curdling State? N/A
Completed NCT03280368 - Adherence and Coagulation Assays in Dabigatran-treated Patients With Atrial Fibrillation
Completed NCT00493272 - Dilutional Coagulopathy in Patients Undergoing Elective Surgery Phase 1/Phase 2
Recruiting NCT02720679 - Investigation of the Genetics of Hematologic Diseases
Completed NCT03972839 - Comparison of Two D-Dimers Dosing Techniques
Completed NCT03734588 - Dose-finding Study of SPK-8016 Gene Therapy in Patients With Hemophilia A to Support Evaluation in Individuals With FVIII Inhibitors Phase 1/Phase 2
Completed NCT03876301 - Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants
Completed NCT00001927 - Study of Abnormal Blood Clotting in Children With Stroke N/A