Clinical Trials Logo

Blood Coagulation Disorder clinical trials

View clinical trials related to Blood Coagulation Disorder.

Filter by:

NCT ID: NCT06403163 Recruiting - Anesthesia Clinical Trials

Transfusion Surveillance in Anaesthesia

STAR
Start date: September 1, 2022
Phase:
Study type: Observational [Patient Registry]

the aim of this register is to collect exhaustively the different data available surrounding a transfusion act in the context of an active haemorrhage. The aim is to allow different modelling and analysis related to emergency transfusion.

NCT ID: NCT06291415 Recruiting - Hemorrhage Clinical Trials

The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Adult Subjects With Immune Thrombocytopenia (ITP)

Start date: April 2, 2024
Phase: Phase 1
Study type: Interventional

This is an open-label, multicenter study to evaluate the safety, tolerability, and efficacy of HMPL-523 in adult subjects with ITP.

NCT ID: NCT06174961 Active, not recruiting - Clinical trials for Blood Coagulation Disorder

The Effect of Exercise on Pharmacodynamics and Pharmacokinetics of a Single Dose of Unfractionated Heparin

Start date: September 22, 2023
Phase: Phase 4
Study type: Interventional

The aim of this project is to assess the influence of exercise on pharmacokinetics (PK) and pharmacodynamics (PD) of a single dose of subcutaneously (sc) administered unfractionated heparin (UFH). It is hypothesized that exercise will increase the systemic exposure (PK) and therefore the clinical effects (PD) of the sc administered UFH. To assess this, healthy male volunteers will be included in a controlled, randomized, crossover study, where they, on four separate days, will have UFH injected sc in the thigh, followed by different exercise interventions (one per experimental day). Blood sampling, with the aim of assessing PK and PD will be performed during the following hours.

NCT ID: NCT05698160 Not yet recruiting - Clinical trials for Blood Coagulation Disorder

Biomarkers and Prediction of Tigecycline Induced Coagulation Dysfunction

Start date: May 1, 2023
Phase:
Study type: Observational [Patient Registry]

This study is to screen out the biomarkers and establish the model to predict coagulation dysfunction induced tigecycline

NCT ID: NCT04896203 Recruiting - Clinical trials for Inflammatory Bowel Diseases

Hypercoagulability Study Using Haemostatic Techniques in Patients With Inflammatory Bowel Disease

EDGAR
Start date: November 18, 2020
Phase:
Study type: Observational

Descriptive study, in which the haemostatic profile of ambulatory patients with IBD will be analyzed by means of ROTEM and other techniques, such as the thrombin generation test and the study of platelet function by flow cytometry.

NCT ID: NCT04507711 Recruiting - Clinical trials for Blood Coagulation Disorder

Palonosetron and Blood Coagulation

Start date: September 16, 2020
Phase: N/A
Study type: Interventional

Palonosetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of palonosetron. The investigators therefore will perform the present study to measure the effect of palonosetron levels using thromboelastography.

NCT ID: NCT04499274 Recruiting - Clinical trials for Blood Coagulation Disorder

Ondansetron and Blood Coagulation

Start date: September 16, 2020
Phase: N/A
Study type: Interventional

Ondansetron may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of ondansetron. The investigators therefore will perform the present study to measure the effect of ondansestron on the blood coagulation pathway according to the drug concentration level using a thromboelastography test.

NCT ID: NCT04272554 Completed - Hemophilia B Clinical Trials

AAV Gene Therapy Screening/Observational Protocol (ECLIPSE)

ECLIPSE
Start date: February 14, 2020
Phase:
Study type: Observational [Patient Registry]

Freeline is developing adeno-associated virus (AAV) vector based gene therapies for a number of diseases and is actively advancing a programme in Haemophilia B (HB). This study aims to collect prospective data to characterise bleeding events and Factor IX (FIX) concentrate consumption in HB patients that can be used as baseline for participants who elect to participate in a subsequent Freeline gene therapy study. The study will also screen participants for antibodies to a novel AAV vector to assess their suitability for inclusion in a Freeline gene therapy treatment study.

NCT ID: NCT04269278 Completed - Clinical trials for Blood Coagulation Disorder

Dexmedetomidine and Blood Coagulation

Start date: February 12, 2020
Phase:
Study type: Observational

Dexmedetomidine may alter whole blood coagulation. However, little is known about the dose-response relationships according to the blood concentration of dexmedetomidine. The investigators have therefore performed the present study to measure the effect of dexmedetomidine on the coagulation pathway according to the drug concentration level using a rotational thromboelastometry test.

NCT ID: NCT03972839 Completed - Clinical trials for Blood Coagulation Disorder

Comparison of Two D-Dimers Dosing Techniques

COMPADDI
Start date: July 1, 2019
Phase:
Study type: Observational

Study of the possibility of substitution of the automated STAGO D-Dimers method with the semi-automated VIDAS method, which is more expensive, longer to implement and requires the use of a dedicated automaton.