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Blood Cancer clinical trials

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NCT ID: NCT00185692 Completed - Leukemia Clinical Trials

Allogeneic Transplantation From Related Haploidentical Donors

Start date: August 2000
Phase: Phase 2
Study type: Interventional

The purpose of the study is to evaluate the feasibility and safety of transplanting CD34+ selected hematopoietic cells from a haploidentical related donor following a nonmyeloablative regimen of total lymphoid irradiation (TLI) and antithymocyte globulin (ATG).

NCT ID: NCT00185640 Completed - Leukemia Clinical Trials

Allogeneic Transplantation Using Total Lymphoid Irradiation (TLI) and Anti-Thymocyte Globulin (ATG) for Older Patients With Hematologic Malignancies

Start date: March 2003
Phase: Phase 2
Study type: Interventional

To measure how frequently and to what degree a complication of transplant cell acute graft versus host disease (GvHD) occurs.

NCT ID: NCT00185614 Completed - Multiple Myeloma Clinical Trials

Non-myeloablative Allogeneic Transplantation for the Treatment of Multiple Myeloma

Start date: August 2000
Phase: Phase 2
Study type: Interventional

Mixed chimerism transplantation is an approach to allogeneic transplants that attempts to decrease regimen-related toxicity by using non-myeloablative preparatory regimens; establish mixed chimerism using low dose total body irradiation along with immunosuppression using cyclosporine and mycophenolate mofetil; suppress graft-vs-host and host-vs-graft reactions to allow a mixed chimeric state to be established, encourage tolerance and prevent graft-vs-host disease (GvHD) during the mixed chimerism period and use donor lymphocyte infusions to convert the patient to a full chimera while developing a graft-vs-tumor effect.