The Effect of Pregabalin on the Spinal Anesthesia

Block Clinical Trial

Official title:

The Effect of Pregabalin on the Spinal Anesthesia: Randomized Controlled Placebo Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02690506
• Other study ID #: 2014-05-027
• Status: Completed
• Phase: N/A
• First received: February 19, 2016
• Last updated: May 17, 2016
• Start date: February 2016
• Est. completion date: May 2016

Study information

• Verified date: May 2016
• Source: Kyungpook National University
• Contact: n/a
• Is FDA regulated: No
• Health authority: South Korea: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Pregabalin, an anticonvulsant is widely used for treatment of neuropathic pain. Recently, it was reported that premedication of pregabalin before general anesthesia is effective to reduce postoperative pain. Up to date, there is no study about the effect of premedication of pregabalin on the spinal anesthesia. Therefore, in this study, investigators investigate the effect of premedication of pregabalin on the spinal anesthesia.

Description:

In this study, investigators investigate the effect of premedication of pregabaline 150 mg on the spinal anesthesia. Two hours before spinal anesthesia, placebo pill was administered to patients in the group C and pregabalin 150 mg was administered to patients in the group P, respectively. Time for the onset of blockade, cephalad level of analgesia and duration of analgesia were measured.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 44
• Est. completion date: May 2016
• Est. primary completion date: May 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 19 Years to 70 Years

Eligibility

Inclusion Criteria:

• Patients of American Society of Anaesthesiologists Grades I and II

Exclusion Criteria:

• Patients with infection at the puncture site, coagulopathy, having true hypersensitivity to drugs used, diabetes and hypertension, psychiatric and neurological diseases

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)

Related Conditions & MeSH terms

• Block

Intervention

Drug:
• Placebo

• Pregabalin

Locations

Country	Name	City	State
Korea, Republic of	Kyungpook National University Hospital	Daegu

Sponsors (1)

Lead Sponsor	Collaborator
Kyungpook National University

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Duration of spinal anesthesia	Duration of spinal anesthesia was measured 24 after spinal anesthesia	24 hours after spinal anesthesia	No