PPI for Prevention of Post-sphincterotomy Bleeding

Status Completed

Clinical Trial Summary

Endoscopic biliary sphincterotomy is a common and important procedure for biliary access and therapy during endoscopic retrograde cholangiopancreatography (ERCP). Bleeding is one of the important complications related to sphincterotomy. This study determines the role of proton pump inhibitor (PPI) in preventing post-sphincterotomy bleeding in patients undergoing ERCP and sphincterotomy.

Clinical Trial Description

Eligible patients will be randomized to receive either high dose PPI or standard care. PPI will be given before ERCP and continue for one week after the sphincterotomy.

Both overt and occult bleeding will be documented up to 10 days after the sphincterotomy. Bleeding rates of the two groups will be compared. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01873079
Study type	Interventional
Source	The University of Hong Kong
Contact
Status	Completed
Phase	Phase 3
Start date	April 2013
Completion date	June 2016

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03678168` - A Comparison Between Conventional Throat Packs and Pharyngeal Placement of Tampons in Rhinology Surgeries	N/A
Completed	`NCT04058223` - Comparison of the Short-term Outcomes of Using DST and PPH Staplers in the Treatment of Grade III and IV Hemorrhoids
Completed	`NCT05669313` - The Effects of Hypothermia and Acidosis on Coagulation During Treatment With Rivaroxaban Measured With ROTEM
Completed	`NCT04590898` - Peri-device Leakage Closure After LAAO
Active, not recruiting	`NCT05563883` - Atrial Fibrillation and Cancer: a Nationwide French Cohort Study
Not yet recruiting	`NCT04537533` - Tranexamic Acid Infusion in Low Dose Versus in High Dose for Reducing Blood Loss in Radical Cystectomy Operations	Phase 4
Withdrawn	`NCT02851940` - Pain and Bleeding Following Hypertonic Saline Sclerotherapy Compared to Brand Ligation for Symptomatic Hemorrhoids	N/A
Completed	`NCT02722720` - Carotid Arteries Stenting Complications: Transradial Approach Versus Transfemoral	N/A
Recruiting	`NCT02279186` - Effectiveness of Intravenous Tranexamic Acid in Reducing Blood Loss During and After Cesarean Section	Phase 4
Active, not recruiting	`NCT02244853` - Heart Rate and Cardiovascular Diseases Prognosis in People With Stable Coronary Artery Disease	N/A
Completed	`NCT02245854` - Efficacy and Safety of a New Polypectomy Snare for Cold-polypectomy for Small Colorectal Polyps	N/A
Completed	`NCT02980497` - Antiplaque/Antigingivitis Efficacy of Essential Oil Mouthrinses in Six-Month Study	N/A
Completed	`NCT02092415` - Assessment of Limb Perfusion During Junctional Tourniquet	N/A
Not yet recruiting	`NCT01438736` - Is Cerazette Use Before Nexplanon Insertion Predictive for Bleeding Pattern?	Phase 4
Completed	`NCT00515541` - Lovaza's Effect on the Activation of Platelets	Phase 2
Completed	`NCT00143715` - Oral Vitamin K for Warfarin Associated Coagulopathy	Phase 3
Terminated	`NCT03954314` - DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery	Phase 3
Recruiting	`NCT05945680` - Tranexamic Acid in Breast Esthetic Surgery.	Phase 4
Recruiting	`NCT03783182` - Betamethasone (Betapred®) as Premedication for Reducing Postoperative Vomiting and Pain After Tonsillectomy	Phase 4
Not yet recruiting	`NCT05464394` - Peroperative Administration of Tranexamic Acid in Roux-en-Y Gastric Bypass and One-anastomosis Gastric Bypass	Phase 3