Bladder Cancer Clinical Trial
Official title:
Zirconium-girentuximab PET in Urothelial Cancer Patients
This phase Ib/II study will evaluate the use of 89Zr-girentuximab in the staging of urothelial carcinoma. The primary objective of this study is to compare the sensitivity and specificity of 89Zr-girentuximab PET with FDG-PET in the staging of urothelial carcinoma.
This study will evaluate the use of 89Zr-girentuximab in the staging of urothelial carcinoma. The primary objective of this study is to compare the sensitivity and specificity of 89Zr-girentuximab PET with FDG-PET in the staging of urothelial carcinoma. The study is open-label, single centre and eligible patients will receive a single administration of study drug prior to imaging on day 5 (+/- 2 days). PET scans will be independently interpreted by nuclear medicine physicians blinded to the FDG PET findings. For patients proceeding to radical cystectomy, subsequent histological confirmation of areas of increased uptake will be retrospectively correlated with both PET scans. ;
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