Bladder Cancer Clinical Trial
Official title:
Expression of Markers Related to Mitochondrial Functionality in Carcinoma of the Urinary Bladder: Comparative Retrospective Analysis Between Recurrent Tumors ("Non-responders") and Non-recurrent Tumors ("Responders") After Intravesical Treatment With Chemotherapy or Immunotherapy
Retrospective monocentric study evaluating different immunohistochemical phenotypes related to mitochondrial functions with treatment outcomes
About 80% of newly diagnosed patients have non-muscle-invasive bladder cancer (NMIBC),
including papillary lesions confined to the urothelium (stage Ta) or invading the lamina
propria (stage T1), and carcinoma in situ (CIS). These tumors show low progression rates, but
high recurrence. In particular, patients with multifocal high-grade urothelial carcinoma have
a high risk of both recurrence (∼70% after 1 yr) and progression (5% after 1 yr). Initial
NMIBC management is a transurethral resection of bladder tumor (TURBT), followed by adjuvant
intravesical treatment with the chemotherapeutic agent Mitomycin C (MMC) or the immunotherapy
Bacillus Calmette-Guérin (BCG). However, these therapies lead to variable clinical responses
and patients recur shortly after surgery. Despite both therapies have been used for decades
in the treatment of NMIBC, at the moment it is not possible to predict after initial staging
which patients will benefit from them since neither resistance mechanisms nor genetic markers
associated to relapse have been identified yet.
In a preliminary analysis, the invesitigators found that low expression of several proteins
involved in mitochondrial functions correlate with a worst prognosis in bladder cancer
patients. The aim of this study is to detect markers of mitochondrial dysfunction by
immunohistochemistry in recurrent tumors ("non-responders") and non-recurrent tumors
("responders") after intravesical treatment with chemotherapy or immunotherapy, and determine
the prognostic relevance of these different markers.
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