Bladder Cancer Clinical Trial
Official title:
A Multicentre Feasibility Study of Online Adaptive Image Guided Radiotherapy for Muscle Invasive Bladder Cancer
The principal objective of the trial is to test the hypothesis that Online Adaptive Radiotherapy for Muscle Invasive Bladder Cancer is feasible across multiple Radiation Oncology departments.
This is a single-arm multicentre feasibility trial in which the primary aim is to determine
the compliance rate of patients to online adaptive radiotherapy for muscle invasive bladder
cancer over multiple Australian and New Zealand centres. The compliance rate is defined as
the proportion of patients successfully completing treatment without a major protocol
deviation.
Subject to the accrual being at least 40 patients in the first 2 years, accrual will
continue until a total of 50 patients have been accrued. If this accrual target is not met,
then consideration will be given to stopping the trial early due to poor accrual. Each
patient will be followed-up until 2 years after the last patient's date of accrual.
Assessments for toxicity and recurrence or progression will take place at four weeks after
completion of treatment, then three monthly from the end of treatment for the first 12
months and then 6 monthly thereafter.
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