Clinical Trials Logo

Birth Asphyxia clinical trials

View clinical trials related to Birth Asphyxia.

Filter by:

NCT ID: NCT05946681 Completed - Stillbirth Clinical Trials

Sildenafil Citrate to Improve Maternal and Neonatal Outcomes in Low-resource Settings

PRISM
Start date: May 16, 2023
Phase:
Study type: Observational

The PRISM pilot feasibility study consists of two phases to determine: 1) to delivery practices, rates of primary and secondary outcomes, and feasibility of enrollment rates, and 2) to assess the feasibility and acceptability of the intervention and expected enrollment rates, and estimate the effect size of sildenafil citrate on maternal and neonatal outcomes in a low resource settings in preparation for the main RCT.

NCT ID: NCT05854745 Active, not recruiting - Neonatal Death Clinical Trials

Comparison of Virtual Training to In-Person Training of Helping Babies Breathe in Ethiopia

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

Helping Babies Breathe (HBB) is a program that teaches providers in low- and middle-income countries about neonatal resuscitation. Historically, HBB training was delivered in person. During the COVID-19 pandemic, many subject matter experts were unable to travel to conduct HBB courses. Innovative methods for teaching HBB are needed to promote the acquisition and retention of resuscitation skills and knowledge.

NCT ID: NCT05707962 Not yet recruiting - Birth Asphyxia Clinical Trials

Neuroprotective Efficacy of Postnatal Magnesium Sulphate in Term Infants With Birth Asphyxia

Start date: March 24, 2023
Phase: N/A
Study type: Interventional

Birth/Perinatal asphyxia in Pakistan continues to be a leading cause of neonatal mortality and morbidity. It is estimated that around 80 to 120,000 neonates either suffer from or die from birth/perinatal asphyxia every year. In addition to the large number of deaths a larger number of babies who survive suffer from neuro-developmental disorders adding to the health burden to the society and the nation. To date other than prevention (which requires global efforts to improve maternal education and health care) the therapies available to treat infants who have suffered from birth asphyxia have been either technically too complex or extremely expensive.

NCT ID: NCT05652738 Completed - Clinical trials for Neonatal Encephalopathy

Passive Cooling Versus Blanket-Roll III on The Myocardial Function of Asphyxiated Neonates

Start date: January 20, 2022
Phase: N/A
Study type: Interventional

Studying the effect of passive versus Blanket roll III modality of therapeutic hypothermia (TH)on myocardial function of asphyxiated neonates through using tissue Doppler (TD).

NCT ID: NCT05349175 Active, not recruiting - Birth Asphyxia Clinical Trials

Augmented Infant Resuscitator (AIR): Transitioning a Novel Behavior Change Innovation to Drive Newborn Ventilation Skills Enhancement

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

Augmented Infant Resuscitator (AIR) is an inexpensive add-on, compatible with nearly every existing bag-valve mask and many types of ventilation equipment. AIR monitors ventilation quality and provides real-time objective feedback and actionable cues to clinicians to both shorten training times and improve resuscitation quality, adoption, retention, and confidence.

NCT ID: NCT05275725 Recruiting - Birth Asphyxia Clinical Trials

Finding Solutions to Thrive After Birth Asphyxia in Africa

SANE-Uganda
Start date: July 1, 2022
Phase: Phase 1
Study type: Interventional

Neonatal encephalopathy (NE) is the third leading cause of under 5-year mortality and contributes substantially to long-term neurological morbidity worldwide. In low-income countries (LICs), families often lack the resources to care for affected children. For those with disabilities, stigma is high, and social and emotional impacts are substantial. Improving our understanding of NE in LICs is crucial if intervention strategies are developed. Providing access to an affordable and easy-to-administer treatment after birth may improve survival, early brain development and later outcome, maximizing developmental potential. The primary objective of this study is to investigate the feasibility, safety and tolerability of administering sildenafil as a neuroprotective/neurorestorative strategy to improve early brain development in a cohort of children with NE in Uganda.

NCT ID: NCT04820504 Completed - Birth Asphyxia Clinical Trials

Augmented Infant Resuscitator to Enhance Newborn Ventilation

AIR
Start date: July 1, 2016
Phase: N/A
Study type: Interventional

Augmented Infant Resuscitator (AIR) is an inexpensive add-on, compatible with nearly every existing bag-valve mask and many types of ventilation equipment. AIR monitors ventilation quality and provides real-time objective feedback and actionable cues to clinicians to both shorten training times and improve resuscitation quality, adoption, retention, and confidence.

NCT ID: NCT04714502 Active, not recruiting - Birth Asphyxia Clinical Trials

Asphyxia Associated Metabolite Biomarker Investigation 2

AAMBI2
Start date: July 2, 2019
Phase:
Study type: Observational

Follow-up of participants of AAMBI1 study at age of at least 2 years. AAMBI1(ClinicalTrials.gov ID: NCT03354208): Verification of biomarkers in a human population for their ability to diagnose the severity of neonatal asphyxia. These biomarkers linked to asphyxia have been identified in animal studies.

NCT ID: NCT04169191 Active, not recruiting - Birth Asphyxia Clinical Trials

Sildenafil to Repair Brain Injury Secondary to Birth Asphyxia

SANE-02
Start date: September 19, 2019
Phase: Phase 1
Study type: Interventional

The investigators will determine the maximum tolerable dose of sildenafil and establish the pharmacokinetic and pharmacodynamic profile of sildenafil in human asphyxiated neonates treated with hypothermia. They will use a 3+3 design to escalate the sildenafil dose up to 6 mg/kg/day (3mg/kg/dose q12h) in asphyxiated neonates demonstrating brain injury despite hypothermia treatment and assess whether we observe any beneficial effects of sildenafil on their brain and cardiopulmonary hemodynamics, without causing serious adverse events

NCT ID: NCT04043299 Recruiting - Birth Asphyxia Clinical Trials

Effect of Intrapartum Oxygen Administration on Fetal and Early Neonatal Outcomes

Intra-O
Start date: March 16, 2020
Phase: Phase 3
Study type: Interventional

Introduction Birth asphyxia is one of leading causes of neonatal mortality in Uganda. It is associated with long term neuro-developmental complications among the babies that survive. Preventive measures for birth asphyxia intrauterine are not clearly understood and thus the need for this study. The aim of the study is to assess the effect of intrapartum oxygen administration on fetal and early neonatal outcomes. Methods A double-blind randomized clinical trial which will be conducted in Gulu regional referral and Kawempe National referral hospitals in Uganda. A total sample size of 1108 women in labour will be enrolled with 554 participants per group. The intervention will include administration of 10 L/min of 100% oxygen for 15 minutes to women in established labor who have signs of fetal distress with fetal heart rate of less than 120 or above 160 beats per minute. The control group will receive medical air (21% oxygen) using the same criteria. Women and babies will be followed up until 7 days after birth to document the outcomes. Statistical analysis to identify difference in outcomes between the control and intervention groups will be performed. Ethical considerations Ethical approval and permission was received from relevant research and ethics committees. Informed consent will be sought from the participants. A data and safety monitoring board will be set up to review periodically the progress of the clinical trial study. Participants will be monitored for adverse events and severe adverse events; reporting will be done according to the research and ethics committee guidelines.