Biotin Ingestion Clinical Trial
Official title:
Investigator-Initiated Study to Evaluate the Effect of Biotin Ingestion On Routine Laboratory Tests
Inaccuracy of laboratory medicine diagnostic tests may be associated with ingestion of over-the-counter biotin supplements.
Study group 1) Due to a lack of systematic studies, little is known about how performance of
specific biotinylated immunoassays is associated with biotin ingestion at doses common in
over-the-counter supplements (10 mg/d) in healthy adults and subjects with thyroid hormone
supplementation. Therefore, this study was designed to assess the association of short-term
biotin ingestion for 10 days with performance of various analytes based on Roche, Abbott and
Siemens assays.
Study group 2) Due to a lack of systematic studies, little is known about how performance of
specific biotinylated immunoassays is associated with biotin ingestion at doses common in
multivitamin supplements (biotin = 50 µg/d) in healthy adults. Therefore, this study was
designed to assess the association of short-term biotin ingestion for 20 days with
performance of various analytes based on Roche, Abbott and Siemens assays.
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