Biomarkers Clinical Trial
Official title:
Association Between Sugar Sweetened Beverage Intake and Biomarkers of Cardiometabolic Risk in US Women
This study is a secondary analysis of data collected in the Nurses' Health Study (NHS) that will evaluat the association between intake of sugar sweetened beverages (SSB), juice and artificially sweetened beverages in relation to biomarkers of hepatic function, lipid metabolism, inflammation and glycemic control.
The investigators will analyze cross-sectional data from 8,492 participants in the Nurses'
Health Study who were free of diabetes and cardiovascular disease to evaluate the
association between intake of sugar sweetened beverages (SSB), juice and artificially
sweetened beverages (ASB) and biomarkers of hepatic function, lipid metabolism, inflammation
and glycemic control. Biomarkers were measured from blood samples that were collected in 2
cycles, approximately 10 years apart.
Specifically, multivariate linear regression will be used to assess the associations of SSB,
ASB, and fruit juice intake with concentrations of fetuin-A, alanine transaminase,
gamma-glutamyl transferase, triglycerides, high-density lipoprotein cholesterol (HDL-C),
low-density lipoprotein cholesterol (LDL-C), total cholesterol, C-reactive protein (CRP),
intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1),
adiponectin, insulin, and hemoglobin A1c as well as total cholesterol/HDL-C ratio.
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