Changes in Biomarkers Associated With Use of Electronic Cigarettes

Status Completed

Clinical Trial Summary

The objective of this clinical trial was to compare the effects of e-cigarettes with and without nicotine on patterns of combustible cigarette use and biomarkers of exposure to tobacco toxicants among African American smokers.

Clinical Trial Description

This study compares patterns of e-cigarette use and the exposure to the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in African American smokers, randomized to ad lib e-cigarettes containing nicotine vs. no nicotine. We hypothesized that nicotine e-cigarettes would be used more than no-nicotine e-cigarettes, and that this would be associated with reduced use of combustible cigarettes. We hypothesized that nicotine e-cigarettes would result in more substitution for combusted cigarettes than no-nicotine e-cigarettes and result in lower levels of exposure to the tobacco-specific carcinogen NNAL. These results would be relevant for developing exposure reduction strategies for adult African American smokers. ;

Study Design

Related Conditions & MeSH terms

Biomarkers

Clinical Trial Details

NCT number	NCT03084315
Study type	Interventional
Source	University of Minnesota
Contact
Status	Completed
Phase	N/A
Start date	November 15, 2016
Completion date	March 8, 2019

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