BIOLOGICAL CLOCKS Clinical Trial
Official title:
Aging,Sleep and Cognitive Process
The aim of the study is to determine the impact of aging, circadian rhythms and sleep deprivation on executive performances. Volunteers will complete a 40-hour extended wakefulness period in constant condition (semi-recumbent posture in bed, constant dim light levels < 10 lux, food and liquid intake at regular intervals) in order to control the circadian system. The volunteers will not be allowed to sleep in the sleep deprivation protocol ("high sleep pressure protocol") and will adopt a short wakefulness/sleep cycle (150/75 minutes) in the multiple nap protocol ("low sleep pressure protocol"). Tests and scales will be repeated every 3H45
Social evolutions (nocturnal activity, shift work) have consequently reduced average sleep
duration average. In addition, aging leads to a physiological reduction of nocturnal sleep
duration.
Many studies have shown that extended wakefulness impairs nocturnal performances measured
with a simple reaction time test (SRTT) and that this decrement is also age-related. In
deed, young subjects (20-30 years) are more affected than old subjects (50-60 years) during
an extended wakefulness period.
The results obtained in confinement constant conditions, associated to a high or low sleep
pressure, show that this difference observed between young and old subjects should be
essentially related to a reduced circadian regulation (ex : reduced melatonin secretion)
with age rather than to a reduced sleep pressure (homeostatic regulation) as previously
suggested. However, studies on confinement have shown that sleep pressure (identified during
the sleep period with the EEG delta band) could be reduced with aging specifically on the
anterior brain regions (frontal regions).
It is well-known that executive performances (related to frontal lobes functioning) are
affected by extended wakefulness, but respective effects of age, circadian system and sleep
pressure in this decrement remain unknown.
The aim of this study is to determine the evolution of the executive functions during a
40-hour extended wakefulness period ("high sleep pressure protocol") or during a multiple
nap protocol ("low sleep pressure protocol") according to the subjects' age, in constant
experimental conditions of confinement.
It's a repeated measurements study with protocol (sleep deprivation and multiple naps) and
time of day as within factors and age group (young versus older subjects) as between factor
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT03276442 -
Biorhythms in Metabolic Tissues
|
N/A |