Biological Aging Clinical Trial
Official title:
A Pilot Study to Explore the Acute Effects of Phytonutrients Upon Muscle Microvascular Blood Flow (Perfusion) in Response to Feeding in Older Adults.
NCT number | NCT03213340 |
Other study ID # | BL31 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | September 14, 2017 |
Est. completion date | October 2, 2019 |
Verified date | January 2020 |
Source | Abbott Nutrition |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.
Status | Completed |
Enrollment | 39 |
Est. completion date | October 2, 2019 |
Est. primary completion date | October 2, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 65 Years and older |
Eligibility |
Inclusion Criteria: - Body mass index (BMI) 18-30 kg/m2 - Free from active metabolic disease - Normotensive Exclusion Criteria: - Habitual gym use or formal exercise (more than once a week) or other routine strenuous physical activity - Smokers - Surgery within past 3 months - Active cardiovascular disease - Taking beta-adrenergic blocking agents - Cerebrovascular disease: - Active respiratory disease - Active metabolic disease - Active inflammatory bowel or renal disease - Active Malignancy or until confirmed remission - Clotting dysfunction - History of DVT - Significant musculoskeletal or neurological disorders - Family history of early (<55y) death from cardiovascular disease - Known sensitivity to Sonovue contrast agent - Known allergy or intolerance to any of the study ingredients - Current use of any of the study ingredients |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Nottingham | Derby |
Lead Sponsor | Collaborator |
---|---|
Abbott Nutrition |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | muscle microvascular blood flow | contrast enhanced ultrasound | Baseline to 240 minutes | |
Secondary | muscle macrovascular blood flow | doppler ultrasound | Baseline to 240 minutes | |
Secondary | central vascular blood flow | echocardiography | Baseline to 90 minutes | |
Secondary | cerebral blood flow | doppler ultrasound | Baseline to 120 minutes | |
Secondary | endothelial function | flow mediated dilation | Baseline to 120 minutes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04224038 -
The Inspire Bio-resource Research Platform for Healthy Aging INSPIRE Platform
|
||
Not yet recruiting |
NCT05760547 -
The Translational Initiative to Map Epigenetics in Aging (TIME-A)
|
||
Recruiting |
NCT05880095 -
Healthy Aging Through Time- Restricted Eating in Adults With Overweight/Obesity and Incipient Liver Disease: ENSATI
|
N/A | |
Completed |
NCT02629666 -
Exercise Referral Schemes Enhanced by Self-Management Strategies to Battle Sedentary Behaviour
|
N/A | |
Recruiting |
NCT03440099 -
Sex-specific Adaptation to Resistance Training in Older Adults
|
N/A | |
Not yet recruiting |
NCT06333301 -
Translational Initiative to Map Epigenetics in Sleep
|