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Evaluation of Increased Absorption of a Curcumin Emulsion (CurQ+) in Healthy Volunteers

Bioavailability Clinical Trial

Official title:
Evaluation of Increased Absorption of a Curcumin Emulsion (CurQ+) in Healthy Volunteers Either Following Enzymatic Hydrolysis Pre-Treatment or Direct Analysis of Split Serum Samples

Clinical Trial Summary

This study is intended to evaluate the comparative effects of direct analysis of serum samples versus pre-treatment with enzymatic hydrolysis in split samples obtained from dosing with a highly absorbed curcumin emulsion product that is commercially available as BIOCURC.

Clinical Trial Description

When curcumin is absorbed by the body, it is primarily found in the bloodstream as curcumin glucuronide (C-gluc) and curcumin sulfate (C-SO4) metabolites. Traditionally bioavailability studies have performed an enzymatic hydrolysis pre-treatment of serum samples with both a glucuronidase and a sulfatase enzyme in order to produce free curcumin for analysis via HPLC. In subsequent years, standards have become available for the metabolites (C-gluc & C-SO4) that make it possible to determine these compound levels directly in serum samples using HPLC-MS-MS. Initial pilot work had indicated that enzymatic hydrolysis was producing falsely elevated results for bioavailability. We wanted to evaluate this in a more formal setting. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04103788
Study type Interventional
Source ESM Technologies, LLC
Contact
Status Completed
Phase N/A
Start date March 27, 2018
Completion date December 13, 2018
View Details
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