Bioavailability Clinical Trial
Official title:
Impact of the Source and Polyphenol-containing Food Matrices on the Bioavailability of Peptan® (Collagen Peptides) in Healthy Subjects
The aim of this study is the comparison of the oral bioavailability of hydroxyproline, a key marker for collagen peptide intake, after ingestion of collagen peptides from different sources, sizes and together with different food matrices, either containing high or low levels of polyphenols.
The absorption (blood) of collagen peptides from bovine, fish and porcine source in different
sizes and administered together with foods of different polyphenol content will be assessed.
Pharmacokinetic parameters (AUC0-6h, Cmax and Tmax) after oral single dose administration
will be determined to estimate the impact of different sources, different peptide sized any
food matrix.
The following objectives will be evaluated exploratory by comparison of pharmacokinetic
parameters from the concentration time curve of hydroxyproline, a key marker of collagen type
I, between:
- different sources of collagen peptides (bovine, fish, porcine)
- different sizes of collagen peptides from cattle
- food matrices impact on uptake of bovine collagen peptides (dissolved in water vs. food
matrix 1 vs. food matrix 2).
Additionally, concentration time curves of further amino acids will be assessed
descriptively.
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