Guided Self-Help for Binge Eating Disorder

Status Completed

Clinical Trial Summary

The proposed study will employ a randomized design to evaluate the efficacy of two group-based guided self-help treatments: Integrative Response Therapy (IRT) and Cognitive Behavior Therapy Guided Self-Help, a treatment of known efficacy, in group-format (CBT-GSHg) in the treatment of Binge Eating Disorder (BED), and explore (1) moderators and mediators of treatment, (2) the relative cost-effectiveness of the two treatments, and (3) between group differences on secondary measures (e.g., eating disorder and general psychopathology).

Clinical Trial Description

The focus of this proposal is on BED among an adult population. Guided self-help treatments (GSH) for BED appear promising and may be more readily disseminated than efficacious specialty treatments such as Cognitive Behavioral Therapy (CBT) and Interpersonal Psychotherapy (IPT) given the latter's administration costs and time requirements. The proposed study uses a new group-based, guided self-help BED treatment called Integrative Response Therapy (IRT). IRT is primarily based upon the affect regulation theory of binge eating (e.g., binge eating is an attempt to alter distressing emotional states), while adding cognitive restructuring techniques. IRT teaches effective ways to cope with aversive emotions and reframe faulty cognitions while reducing vulnerabilities that are likely to lead to problematic emotional responding & cognitions such as physical needs (e.g., hunger, sleep deprivation), interpersonal conflict, and, when possible, unpleasant external events. IRT's primary goal is to significantly decrease episodes of binge eating and associated eating disorder pathology.

CBT-GSH is a frequently used manual-based form of GSH that has demonstrated efficacy. CBT, based on the restraint model, intervenes via behavioral techniques to replace restrained eating with more regular eating patterns and cognitive techniques to restructure an individual's problematic thoughts that over-evaluate shape and weight. Research literature indicates that CBT-GSH is a viable self-help BED treatment that appears to be superior to wait-list control conditions, equivalent to IPT, a specialty treatment, and superior to Behavioral Weight Loss treatment at 2-year follow-up. There are then, a number of reasons for further research on GSH in general and CBT-gsh specifically.

The proposed study will lay the groundwork for identifying which GSH treatment should be investigated in a subsequent, larger trial that would evaluate a clinically relevant algorithm for the treatment of BED. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01282736
Study type	Interventional
Source	Stanford University
Contact
Status	Completed
Phase	N/A
Start date	June 2010
Completion date	July 2014

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT02978742` - Evaluating and Implementing a Smartphone Application Treatment Program for Bulimia Nervosa and Binge Eating Disorder	N/A
Recruiting	`NCT02659488` - Lisdexamfetamine in Binge Eating Disorder (BED): fMRI Effects	Phase 2
Completed	`NCT02659475` - Phentermine/Topiramate Extended Release in Binge Eating Disorder (BED)	Phase 2
Completed	`NCT00601653` - Effectiveness of Cognitive Behavioral Therapy Plus Nutritional Counseling in Promoting Weight Loss in People With Binge Eating Disorder	N/A
Completed	`NCT02834299` - Dialectical Behavior Therapy Guided Self-Help for Binge Eating Disorder	N/A
Completed	`NCT02553824` - FDA Approved Medication to Reduce Binge Eating and/or Purging	Phase 1
Completed	`NCT02564588` - Dasotraline Binge Eating Disorder Study	Phase 2/Phase 3
Completed	`NCT00307190` - Hormone Release and Stomach Disturbances in People With Binge Eating Disorder	N/A
Completed	`NCT01718509` - SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder	Phase 3
Completed	`NCT01718483` - SPD489 in Adults Aged 18-55 Years With Moderate to Severe Binge Eating Disorder	Phase 3
Completed	`NCT02503098` - Optimizing a Smartphone Application for Individuals With Eating Disorders	N/A
Active, not recruiting	`NCT01837953` - Stepped Care for Binge Eating Disorder: Predicting Response to Minimal Intervention in a Randomized Controlled Trial	N/A
Completed	`NCT01010789` - Armodafinil in Binge Eating Disorder (BED)	Phase 3
Completed	`NCT01098435` - ALK33-101: A Study of RDC-0313 (ALKS 33) in Adults With Binge Eating Disorder	Phase 2
Completed	`NCT01552759` - Appetite Hormones in Binge Eating Disorder	N/A
Completed	`NCT00330655` - An Open-Label Trial of Memantine in the Treatment of Binge Eating Disorder	Phase 4
Completed	`NCT01291173` - Forced-dose Titration of SPD489 in Adults With Binge Eating Disorder	Phase 2
Completed	`NCT03107026` - A Study to Evaluate a Drug (Dasotraline) on the Safety, Effectiveness and How Well the Body Tolerates it, in Adults With Moderate to Severe Binge Eating Disorder	Phase 3
Completed	`NCT02079935` - Treatment of Eating Disorders by Physical Activity and Nutrition Counseling	N/A
Completed	`NCT00277641` - Lamotrigine in the Treatment of Binge Eating Disorder Associated With Obesity	Phase 3