Apatinib as Second Line Therapy in Patients With Advanced Refractory Biliary Tract Cancers

Biliary Tract Cancer Clinical Trial

Official title:

Phase II Study of Apatinib as Second Line Therapy in Patients With Advanced Refractory Biliary Tract Cancer

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03144856
• Other study ID #: Apatinib_BTC
• Status: Recruiting
• Phase: Phase 2
• First received: May 5, 2017
• Last updated: May 8, 2017
• Start date: February 22, 2017
• Est. completion date: March 1, 2019

Study information

• Verified date: May 2017
• Source: Sun Yat-sen University
• Contact: Feng-Hua Wang, MD, PhD
• Phone: 86-020-87342490
• Email: wangfh[@]sysucc.org.cn
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study is designed to see whether Apatinib is effective in treating patients with advanced refractory biliary tract cancers.

Description:

Biliary tract cancers (BTC) includes cholangiocarcinoma and gallbladder carcinoma (GBC). The systematic treatment based on gemcitabine plus cisplatin is recommended as the current standard chemotherapy for unresectable or metastatic BTC. There is no standard recommendation for second line therapy.

Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2).

This study was conducted to assess the efficacy and safety of Apatinib in patients with advanced refractory BTC who had received first-line chemotherapy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 39
• Est. completion date: March 1, 2019
• Est. primary completion date: March 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. Must have histologically or cytologically documented carcinoma primary to the intra- or extra-hepatic biliary system or gall bladder with clinical and/or radiologic evidence of unresectable, locally advanced or metastatic disease.

2. Patients with ampullary carcinoma are not eligible.

3. Must have failed or are intolerant to one line of systemic treatment but no more than 2 prior lines of systemic chemotherapy for advanced BTC. Patients who received adjuvant chemotherapy and had evidence of disease recurrence within 6 months of completion of the adjuvant treatment are also eligible. If the patient received adjuvant treatment and had disease recurrence after 6 months, patients will only be eligible after failing or having intolerance to one line of systemic chemotherapy used to treat the disease recurrence.

4. Age between 18 and 75 years old

5. Eastern Cooperative Oncology Group (ECOG) Performance Status Assessment of 0 or 1.

6. Must have radiographic measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.

7. Life expectancy of at least 12 weeks (3 months).

8. For patients who have received prior radiation, cryotherapy, radiofrequency ablation, therasphere, ethanol injection, transarterial chemoembolization (TACE) or photodynamic therapy, the following criteria must be met: 28 days have elapsed since that therapy; Lesions that have not been treated with local therapy must be present and measureable.

9. Must be able to understand and be willing to sign the written informed consent form. Must be willing and able to comply with scheduled visits, treatment schedule, laboratory testing, and other study requirements.

10. All acute toxic effects of any prior treatment have resolved to NCI-CTCAE v4.0 Grade 1 or less at the time of signing the Informed Consent Form (ICF) except for alopecia.

11. Adequate bone marrow, liver and liver function.

12. Women of childbearing potential must have a negative serum pregnancy test performed within 7 days prior to the start of study drug.

13. Men and women of childbearing potential must agree to use adequate contraception beginning at the signing of the ICF until at least 3 months after the last dose of study drug.

Exclusion Criteria:

1. Pregnant or lactating women;

2. History of other malignancies except cured basal cell carcinoma of skin and carcinoma insitu of uterine cervix;

3. Uncontrolled hypertension;

4. Intercurrence with one of the following: coronary artery disease, arrhythmia and heart failure;

5. Urine protein>grade 1;

6. Any factors that influence the usage of oral administration;

7. Patients with a clear tendency of gastrointestinal bleeding;

8. Abnormal coagulation function(INR=1.5, APTT=1.5 ULN);

9. Abuse of alcohol or drugs;

10. Less than 4 weeks from the last clinical trial;

11. Prior treatment with antivascular endothelial growth factor or the other anti angiogenesis therapy;

12. Active central nervous system (CNS). If CNS metastases are treated and potential participants are at neurologic baseline for at least 2 weeks prior to enrollment, they will be eligible but will need a Brain MRI prior to enrollment. 13. Disability of serious uncontrolled intercurrence infection.

Related Conditions & MeSH terms

• Biliary Tract Cancer
• Biliary Tract Neoplasms

Intervention

Drug:
• Apatinib
Apatinib 500mg, po, qd, every 4 weeks.

Locations

Country	Name	City	State
China	Foshan people's Hospital	Foshan	Guangdong
China	Cancer center of Sun Yat-sen University	Guangzhou	Guangdong

Sponsors (2)

Lead Sponsor	Collaborator
Sun Yat-sen University	Jiangsu HengRui Medicine Co., Ltd.

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Progression-free survival (PFS)	the time from randomize to progression or death; RECIST guidelines were used to define all responses after patients had received every 4 weeks of therapy	Approximately 1 year
Secondary	Overall survival (OS)	Defined as the time from randomize to death	Approximately 2 years
Secondary	Disease control rate(DCR)	Defined as the rate of complete response , partial response and stable disease according to RECIST guidelines	Approximately 1 year
Secondary	Quality of life(QoL)	As measured by the European Organization for Research and Treatment of Cancer questionnaire (EORTC QLQ C30)	Approximately 1 year
Secondary	Safety (incidence of adverse events)	Incidence of adverse events	Approximately 1 year