Beta Thalassemia Clinical Trial
Official title:
Evaluation of Heart Status in Patients of Beta Thalassemia Using Echocardiogram
Heart failure from myocardial iron deposition is a severe complication for patients with transfusion-dependent beta thalassemia . Increased cardiac iron content impacts the contractility of cardiomyocytes and can also lead to myocarditis, pericarditis, and arrhythmias. The severity of cardiac dysfunction depends on the amount of iron deposited in the myocardium.Echocardiogram is used as noninvasive method to observe heart status. The objective of this study is to evaluate the heart status in patients of Beta Thalassemia from southern China.
| Status | Recruiting |
| Enrollment | 1200 |
| Est. completion date | December 30, 2025 |
| Est. primary completion date | July 1, 2024 |
| Accepts healthy volunteers | |
| Gender | All |
| Age group | N/A and older |
| Eligibility | Inclusion Criteria: - Diagnosed with beta-thalassemia Exclusion Criteria: - Iron deficiency anemia |
| Country | Name | City | State |
|---|---|---|---|
| China | Southern Medical University | Guangzhou | Guangdong |
| Lead Sponsor | Collaborator |
|---|---|
| Nanfang Hospital of Southern Medical University | Jiangmen Maternity and Child Health Care Hospital, Shenzhen Children's Hospital, Shenzhen Second People's Hospital, Yongzhou Maternity and Child Health Hospital, ZhuHai Hospital |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Echocardiogram | Evaluation of heart function in beta thalassemia patients by left ventricular fraction shortening | 3 years |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01049854 -
CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant
|
Phase 2 | |
| Active, not recruiting |
NCT00408447 -
Stem Cell Transplant in Sickle Cell Disease and Thalassemia
|
Phase 2 | |
| Completed |
NCT02597595 -
Effects of Spirulina on Cardiac Functions in Children With Beta Thalassemia Major
|
N/A | |
| Recruiting |
NCT06073860 -
A Post-Marketing Surveillance Study to Assess Safety of Luspatercept in Korean Patients With Myelodysplastic Syndrome or β-thalassemia
|
||
| Recruiting |
NCT05357482 -
Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia
|
Phase 1/Phase 2 | |
| Completed |
NCT00790127 -
Phase 1/2 Study of HQK-1001 in Patients With Beta Thalassemia
|
Phase 1/Phase 2 | |
| Completed |
NCT00005934 -
5-Azacytidine and Phenylbutyrate to Treat Severe Thalassemia
|
Phase 2 | |
| Completed |
NCT01931644 -
At-Home Research Study for Patients With Autoimmune, Inflammatory, Genetic, Hematological, Infectious, Neurological, CNS, Oncological, Respiratory, Metabolic Conditions
|
||
| Completed |
NCT00159042 -
Genetic Factors Affecting the Severity of Beta Thalassemia
|
N/A | |
| Recruiting |
NCT04918056 -
Genetic Variants Affecting the Clinical Severity of Beta Thalassemia
|
||
| Completed |
NCT00001958 -
Hydroxyurea to Treat Beta-Thalassemia (Cooley's Anemia)
|
Phase 2 | |
| Recruiting |
NCT04917978 -
Association of Hb F Level With Clinical Severity of Beta Thalassemia
|