Benzodiazepines Therapeutic Use Clinical Trial
Official title:
Implementation Strategies Aimed at a Simple Patient-directed Intervention to Reduce Long-term Use of Benzodiazepines in Dutch Community Pharmacies
The purpose of this study is to compare the effect of two implementation strategies for a simple patient-directed intervention to reduce long-term benzodiazepine use in Dutch community pharmacies.
| Status | Completed |
| Enrollment | 20000 |
| Est. completion date | December 2006 |
| Est. primary completion date | December 2006 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - benzodiazepine use for more than 3 months in the last 12 months AND for more than 60 days in the last 2 months Exclusion Criteria: - treatment by psychiatrist, treatment of alcohol- or drug misuse, psychotic episodes in history, epilepsy, terminal disease, not mastering the Dutch language, individual criteria used by the family practitioner |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label
| Country | Name | City | State |
|---|---|---|---|
| Netherlands | Apotheek Asten | Asten | |
| Netherlands | Apotheek Bakel-Milheeze | Bakel | |
| Netherlands | Kring-apotheek Bergeyk | Bergeyk | |
| Netherlands | Apotheek Berlicum | Berlicum | |
| Netherlands | Apotheek de Schakel | Best | |
| Netherlands | Apotheek Heivelden | Best | |
| Netherlands | Lloyds Apotheek van Kollenburg | Best | |
| Netherlands | Apotheek Blanckenburgh | Beuningen | |
| Netherlands | Apotheek Bladel | Bladel | |
| Netherlands | Apotheek Bocholtz | Bocholtz | |
| Netherlands | Apotheek van de Wouw | Brunssum | |
| Netherlands | Apotheek Budel | Budel | |
| Netherlands | Apotheek Cleij | Den Bosch | |
| Netherlands | Apotheek Empel | Den Bosch | |
| Netherlands | Apotheek Schellekens | Den Bosch | |
| Netherlands | Apotheek de Schelde | Deurne | |
| Netherlands | Apotheek in 't Groen | Deurne | |
| Netherlands | Apotheek Koolen-Motké | Deurne | |
| Netherlands | Apotheek Druten | Druten | |
| Netherlands | Apotheek de Kempen | Eersel | |
| Netherlands | Apotheek Elsloo | Elsloo | |
| Netherlands | Apotheek Ewijk | Ewijk | |
| Netherlands | Apotheek Eygelshoven | Eygelshoven | |
| Netherlands | Lloyds Apotheek Geldrop | Geldrop | |
| Netherlands | Apotheek het Frans Brugske | Gemert | |
| Netherlands | Apotheek Lindner | Gemert | |
| Netherlands | Apotheek de Duivenakker | Gennep | |
| Netherlands | Apotheek Gennep | Gennep | |
| Netherlands | Apotheek de Goese Polder | Goes | |
| Netherlands | Apotheek de Pijlers | Goes | |
| Netherlands | Zeeuwse Apotheek | Goes | |
| Netherlands | Apotheek Groesbeek | Groesbeek | |
| Netherlands | Linde apotheek | Hapert | |
| Netherlands | Apotheek Heeswijk-Dinther | Heeswijk-Dinther | |
| Netherlands | Apotheek Brouwhuis | Helmond | |
| Netherlands | Apotheek de Luifel | Helmond | |
| Netherlands | Apotheek Tendijck | Helmond | |
| Netherlands | Kring-apotheek de Rijpel | Helmond | |
| Netherlands | Service Apotheek de Bus | Helmond | |
| Netherlands | Service apotheek Vondellaan | Helmond | |
| Netherlands | Lloyds Apotheek Herkenbosch | Herkenbosch | |
| Netherlands | Apotheek Hegtermans | Herten | |
| Netherlands | Apotheek Herten-Merum | Herten | |
| Netherlands | Apotheek Bleijerheide | Kerkrade | |
| Netherlands | apotheek Kerkrade-centrum | Kerkrade | |
| Netherlands | Apotheek Medische Centrum West Kerkrade | Kerkrade | |
| Netherlands | Apotheek Schonefeld | Kerkrade | |
| Netherlands | Apotheek Terwinselen | Kerkrade | |
| Netherlands | Apotheek Landgraaf | Landgraaf | |
| Netherlands | Apotheek MC Putstraat | Landgraaf | |
| Netherlands | Apotheek Nieuwenhagen | Landgraaf | |
| Netherlands | Apotheek Schaesberg | Landgraaf | |
| Netherlands | Apotheek Waubach | Landgraaf | |
| Netherlands | Apotheek Maarheeze | Maarheeze | |
| Netherlands | Apotheek Craveld | Maasbracht | |
| Netherlands | Apotheek Maasbracht | Maasbracht | |
| Netherlands | Service apotheek Malden | Malden | |
| Netherlands | Apotheek Maasdorpen | Meerlo | |
| Netherlands | Lloyds Apotheek de Roerstreek | Melick | |
| Netherlands | Apotheek Dauwendaele | Middelburg | |
| Netherlands | Apotheek Hummelen | Middelburg | |
| Netherlands | Apotheek Ringeling | Middelburg | |
| Netherlands | Apotheek Stromenwijk 't Zand | Middelburg | |
| Netherlands | Apotheek Welsinge | Middelburg | |
| Netherlands | Apotheek van der Ploeg | Nijmegen | |
| Netherlands | Kring-apotheek Beckers | Nijmegen | |
| Netherlands | Apotheek Souburg | Oost-Souburg | |
| Netherlands | Lloyds Apotheek Postert | Posterholt | |
| Netherlands | Apotheek Reusel | Reusel | |
| Netherlands | Apotheek Hendrickx-Maasniel | Roermond | |
| Netherlands | Apotheek Roermond Zuid | Roermond | |
| Netherlands | Lloyds Apotheek Clemens-Haan | Roermond | |
| Netherlands | Lloyds Apotheek Donderberg | Roermond | |
| Netherlands | Reinald apotheek | Roermond | |
| Netherlands | Apotheek Rosmalen | Rosmalen | |
| Netherlands | Apotheek Rosmalen-Walschot | Rosmalen | |
| Netherlands | apotheek Simpelveld-Bocholtz | Simpelveld | |
| Netherlands | Apotheek Hopveld | Sint Michielsgestel | |
| Netherlands | Apotheek de Baandert | Sittard | |
| Netherlands | Wandelbos Apotheek | Tilburg | |
| Netherlands | Apotheek de Belleman | Valkenswaard | |
| Netherlands | Apotheek Dommeldal | Valkenswaard | |
| Netherlands | Apotheek Valkenswaard | Valkenswaard | |
| Netherlands | Apotheek Vlaslant | Valkenswaard | |
| Netherlands | apotheek 't Zuid | Veghel | |
| Netherlands | Apotheek Zonderwijk | Veldhoven | |
| Netherlands | Veldhovense Apotheek | Veldhoven | |
| Netherlands | Apotheek Dr. H. Kilian | Wijchen | |
| Netherlands | Apotheek van Poppel | Wijchen | |
| Netherlands | Apotheek Wijchen-Zuid | Wijchen |
| Lead Sponsor | Collaborator |
|---|---|
| Radboud University | Scientific Institute for Dutch Pharmacists, The Netherlands, Zorgverzekeraar CZ |
Netherlands,
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* Note: There are 15 references in all — Click here to view all references
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | percentage of general practitioners that reviewed and returned the list of longterm users. | |||
| Primary | percentage of letters sent by the pharmacists in the four months after receiving the manual. | |||
| Primary | percentage of long-term benzodiazepine users that managed to quit or significantly reduce their use in months 0-3, 4-6 and 10-12 after receiving the letter. | |||
| Secondary | evaluation of the implementation strategies |