Benzodiazepine Dependence Clinical Trial
Official title:
Electroacupuncture for Tapering Off Long-term Benzodiazepine Use: a Randomized Controlled Trial
This study aims to examine the efficacy of electroacupuncture for tapering benzodiazepines in long-term users. All eligible subjects will be randomized in a ratio of 1:1 to (1) Electroacupuncture combined with gradual tapering; and (2) Placebo acupuncture combined with gradual tapering.
Recent randomized controlled studies support that acupuncture has beneficial effects for
insomnia. Primary insomnia patients receiving electroacupuncture showed an increase in sleep
diary-derived sleep efficiency from an average of 69.8% at baseline to 81.2% at 1-week
post-treatment. A similar result was found in patients with residual insomnia associated
with major depressive disorder.
Acupuncture is efficacious in alleviating anxiety and insomnia symptoms; hence, it may help
to reduce the impacts of withdrawal symptoms during benzodiazepine tapering. However, there
has been no randomized controlled trial to examine the efficacy and safety of acupuncture on
benzodiazepine discontinuation.
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