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Effect of Dutasteride on HIF-1alpha and VEGF in the Prostate

Benign Prostatic Hyperplasia Clinical Trial

Official title:
Apoptosis and Expression of Neovascularization-related Factors in Human Prostate Tissue After Administration of Dutasteride

Clinical Trial Summary

The purpose of this study is to determine whether dutasteride may influence the expression of angiogenesis factors such as hypoxia inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF) in patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH).

Clinical Trial Description

A total of 41 patients awaiting transurethral resection of the prostate (TURP) will be divided into two groups (1:1); twenty patients will receive no medication and 21 will receive 0.5 mg dutasteride daily for 2 to 4 weeks until TURP. In both groups, the extent, intensity and intracellular location of hypoxia inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)will be evaluated. Microvessel density will be also compared in the two groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00880672
Study type Interventional
Source Seoul National University Hospital
Contact
Status Completed
Phase Phase 4
Start date January 2008
Completion date April 2009
View Details
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