Screening for Prognostic Biomarkers of Severe Bell's Palsy in Adults

Bell Palsy Clinical Trial

— BIOFIPS  

Official title:

Screening for Prognostic Biomarkers of Severe Bell's Palsy in Adults Using Proteomic Analysis by Quantitative Mass Spectroscopy

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05582915
• Other study ID #: RECHMPL22_0036
• Status: Recruiting
• Start date: January 3, 2023
• Est. completion date: August 2024

Study information

• Verified date: May 2024
• Source: University Hospital, Montpellier
• Contact: Anne-Lise Fourez, MD
• Phone: +334 67 33 68 90
• Email: al-fourez[@]chu-montpellier.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Bell's palsy (idiopathic peripheral facial palsy) is the most common cause of facial palsy, which is related to the inflammation of the facial nerve, possibly induced by herpesvirus reactivation. Its first-line treatment comprises corticosteroids, antiviral therapy and physiotherapy. In most severe cases (grade IV to VI on House-Brackmann scale), facial motricity may remain altered or develop synkinesis or post-paralytic spasm, thus tremendously affecting quality of life. To avoid potential complications, surgical facial nerve decompression could be proposed. To date, however, there are no means to predict if Bell's palsy will evolve with any complications or if the patient will recover entirely. Thus, the invasive facial nerve decompression is equally proposed to subjects who will develop the consequences as well as to subjects able to restore without surgical treatment. This study proposes to search for prognostic blood biomarkers related to the Bell's palsy recovery pattern. Adult patients with severe Bell's palsy will be proposed to have a blood sampling for proteomic analysis in the early stage of the disease. Then 125 biomarkers on a Peptiquant™ kit will be analysed by mass spectrometry, and prognostic biomarkers will be selected regarding to the clinical recovery of Bell's palsy

Description:

Bell's palsy (idiopathic peripheral facial palsy) is the most common cause of facial palsy, which is related to the inflammation of the facial nerve, possibly induced by herpesvirus reactivation. Its first-line treatment comprises corticosteroids, antiviral therapy and physiotherapy. In most severe cases (grade IV to VI on House-Brackmann scale), facial motricity may remain altered or develop synkinesis or post-paralytic spasm, thus tremendously affecting quality of life. The recovery of Bell's palsy is currently evaluated either by Sunnybrook Facial Grading System, House-Brackmann scale or Chevalier's method. It is nonetheless unpredictable, especially at the early stage of the disease.

If the first-line treatment fails to provide a fast recovery, facial nerve decompression surgery may be proposed. Being rather complex and risky, this technique shows a lower efficiency if delayed from the onset. Surgical indication is based upon clinical and radiological criteria as well as electrophysiological measurements (electromyography - EMG and electromyoneurography - EMNG). EMG and ENMG methods have a somewhat limited predictive value, since 20 to 40% patients with severe Bell's palsy can recover without surgical treatment. Moreover, these measurements are not widely accessible and, in severe cases, they should be performed between 9 and 20 days from the onset. The surgery, in order to increase its success rate, should be performed in maximum 30 days, ideally in 14 days from the onset.

Therefore, diagnostic and treatment of severe Bell's palsy face a double challenge: a narrow time window to provide a diagnostic and therapeutic strategy, and the need of a reliable prognostic methods to exclude the possibility of spontaneous recovery and thus to justify the surgical approach.

Mass Spectrometry assay allows simultaneous detection of numerous proteins, to screen for inflammatory and neurodegenerative biomarkers at acute stage of Bell's palsy. Some of these proteins might appear of a prognostic value and will help to develop more reliable and personalised treatment approach of severe Bell's palsy.

The primary objective of the study is to identify prognostic blood biomarkers related to the facial motricity recovery at 3 months from onset of severe Bell's palsy in adults.

The secondary objectives are identification of the biomarkers related to the recovery speed in the first three months, and to the initial severity of Bell's palsy; evaluation of diagnostic performance of selected biomarkers; creation of a blood collection for further research on selected biomarkers.

130 patients referred by accident and emergency department will be enrolled during their appointments at the ENT Department of the University Hospital of Montpellier. BIOFIPS study implies 4 visits, with the overall duration of 3 months per patient. After patient information and consent, routine clinical examination, audiometric testing, tympanometry, acoustic reflex testing and Bell's palsy scoring will be performed. Patients will receive a medical prescription for a blood test an MRI to exclude other causes of facial palsy. At time of inclusion and 1 month after, they will be proposed to have a blood sampling for proteomic analysis. Then 125 biomarkers on a Peptiquant™ kit will be analysed by mass spectrometry, and prognostic biomarkers will be selected regarding to the clinical recovery of Bell's palsy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 130
• Est. completion date: August 2024
• Est. primary completion date: August 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Severe Bell's palsy (House-Brackmann more or equal to IV)

• Disease developed between 5 and 15 days before V0 (after initial corticotherapy)

• 18 years and older

Exclusion Criteria:

• Facial palsy (central or peripheral) of a following cause suspected at V0:

Diabetes, syphilis, HIV-1 or HIV-2 infection, Lyme disease, herpes zoster infection of the geniculate ganglion; Inflammatory or immune pathology, acute or chronic; Intracranial, parotid or facial nerve tumor; Craniofacial injury; Other peripheral neuropathy

• Anti-inflammatoty, immunomodulating, immunosuppressive treatment

• Contraindications for an MRI scan

• Contraindications for a standard medical treatment: prednisone 1 mg per kg a day during 5 days and valaciclovir 3 g a day during 7 days

• Contraindications for or an impossibility of facial physiotheraphy (2 times per week along with everyday self-theraphy)

• Pregnancy or breastfeeding

• Participation to another interventional study

• Patient unaffiliated to French Social Security regime

• Patients' refusal to consent to participation in the study

• Person prived of liberty by judicial or administrative decision

• Person protected by law (under guardianship or curatorship)

• Person not able to understand the nature, the aim and the methodology of the study

Related Conditions & MeSH terms

• Bell Palsy
• Facial Paralysis
• Paralysis

Intervention

Diagnostic Test:
• Blood sampling
4 ml of blood will be collected into EDTA tube for proteomic analysis at visit 0 and visit 1

Locations

Country	Name	City	State
France	CHU Montpellier	Montpellier

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Montpellier

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Area under the ROC curve of biomarkers (from initial sampling) for prognosis of facial motricity recovery at 3 months	"no recovery" group: gain (Visit 3-Visit 0) <40% on Chevalier score vs. "recovery" group: gain (Visit 3-Visit 0) =40% on Chevalier score.; Chevalier score is a clinical scale that evaluates the percentage of facial motricity regarding 15 facial muscles.	Visit 0, Visit 1, Visit 2 and Visit 3 (3 months)
Secondary	Biomarkers related to the speed of recovery in the first 3 months	Biomarkers (value or kinetic between Visit 0 and Visit 1 samples) related to the speed of recovery in the first 3 months: no recovery vs. recovery of PFPI	Visit 0, Visit 1, Visit 2 and Visit 3
Secondary	Biomarkers related to the initial severity of Bell's palsy	Biomarkers at Visit 0 related to the initial severity of Bell's palsy (House and Brackmann score): HB IV vs. IPF HB V vs. IPF HB VI	Visit 0
Secondary	Diagnostic value of selected biomarkers	specificity, positive and negative predictive value	Visit 0, Visit 1, Visit 2 and Visit 3