Clinical Trials Logo

Clinical Trial Summary

The goal of this study is to examine the efficacy of 1gram/day intravenous pulses of methylprednisolone on 3 consecutive days in Behcet's patients with ocular involvement. A total of 34 Behcet's patients referring to Behcet's clinic in Shariati hospital whose problem was confirmed with new international criteria of Behcet's disease (ICBD) will be randomly assigned into one of the two equal groups of intervention or control. Behcet's patients are those with ocular involvement who were under the same cytotoxic treatment with cyclophosphamide and azathioprine. For the patients in the intervention group, intravenous infusion of 1000 mg methylprednisolone in 100cc D/w 5% or 100cc D/w5% on 3 consecutive days will be added to treatment diet. Then treatment will begin with oral prednisolone, 0.5 mg/kg. After that, all the patients were followed up with no other therapeutic intervention by study group. The patients will be visited every 2 months by an ophthalmologist and study group for 6 months in 3 settings. To estimate the ocular inflammation of patients, we use visual acuity, retinal and ocular posterior chamber inflammation index.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Treatment


Related Conditions & MeSH terms


NCT number NCT01306955
Study type Interventional
Source Tehran University of Medical Sciences
Contact Farhad Shahram, Professor
Phone 0098-21-8802-6956
Email Shahramf@tums.ac.ir
Status Recruiting
Phase Phase 4
Start date February 2010
Completion date August 2011

See also
  Status Clinical Trial Phase
Recruiting NCT05635266 - Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
Completed NCT02190916 - Vasculitis Illness Perception (VIP) Study N/A
Completed NCT04065672 - Low-dose IL-2 Treatment on Behcet's Disease Phase 2
Recruiting NCT02593565 - Vasculitis Pregnancy Registry
Completed NCT00167583 - Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Phase 3
Completed NCT03371095 - Induction Therapy With Anti-TNFα vs Cyclophosphamide in Severe Behçet Disease Phase 3
Completed NCT01960790 - Special Investigation in Patients With Intestinal Behcet's Disease (All Case Investigation)
Completed NCT03531385 - Assessment of Central Sensitization, Neuropathic Pain, Sleep Quality and Daily Life Activities in Behcet's Disease
Completed NCT02190942 - VCRC Patient Contact Registry Patient-Reported Data Validation Study
Completed NCT04328064 - The Role of Rosuvastatin on Vascular Involvement in Behçet's Disease N/A
Not yet recruiting NCT06285539 - Drug Rediscovery for Rare Immune Mediated Inflammatory Diseases Phase 2
Completed NCT02190929 - Educational Needs of Patients With Systemic Vasculitis N/A
Completed NCT02476292 - Impact of Vasculitis on Employment and Income N/A
Completed NCT03543709 - Evaluation of Fibromyalgia With Disease Activity and Clinical Findings in Women With Behçet's Disease
Recruiting NCT01793168 - Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
Completed NCT01988506 - Induction of Regulatory t Cells by Low Dose il2 in Autoimmune and Inflammatory Diseases Phase 2
Recruiting NCT01952275 - Observational Study of the Genetic Architecture of Neutrophil-Mediated Inflammatory Skin Diseases N/A
Completed NCT01532570 - Clinical Study of TA-650 in Patients With Behcet's Disease (BD) With Special Lesions Phase 3
Completed NCT03410290 - Journey of Patients With Vasculitis From First Symptom to Diagnosis
Completed NCT02176070 - Reproductive Health in Men and Women With Vasculitis N/A