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NCT05027854 Clinical Trial

Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI

Behavior and Behavior Mechanisms Clinical Trial

Official title:
Brain Network Mechanisms Causally Underlying Human Decisions Revealed by Brain Stimulation and Functional MRI

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05027854
Other study ID # 2020-01490
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date September 1, 2021
Est. completion date September 30, 2025

Study information
Verified date August 2021
Source University of Zurich
Contact Christian Ruff, PhD
Phone +41 44 634 50 67
Email christian.ruff@econ.uzh.ch
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

We will examine how stimulation of specific brain areas with transcranial magnetic stimulation (TMS) or transcranial electric stimulation (tES) changes specific aspects of behavior and brain activity, in order to test hypotheses about brain behavior relationships (basic research).

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 1800
Est. completion date September 30, 2025
Est. primary completion date September 30, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - between 18 and 80 years of age (whereby for most studies the majority of recruited participants will be between 18 and 40 years of age) - right-handedness and/or one specific gender (male or female) can be inclusion criteria to reduce variation in the data. Exclusion Criteria: - inability to understand the instructions and insufficient knowledge of the project language - Internal electronic and/or metallic objects in the head, neck, or shoulders (e.g. artificial cochleae, deep brain stimulators, medical pumps, shrapnel, metallic splinters due to accidents during metal welding) - One or more epileptic fits in the participant or a first-degree relative - Vascular, traumatic, tumoral, infectious, or metabolic brain damage - Use of medication that significantly alters cortical excitability - Acute sleep deprivation or withdrawal from alcohol - pregnancy - to reduce bias, students of psychology or economics can be excluded if there is a possibility that they are familiar with the relevant paradigm.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• TMS or tES
Transcranial magnetic or electric stimulation
• sham TMS or tES
Sham transcranial magnetic or electric stimulation

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Christian Ruff

Outcome
Type Measure Description Time frame Safety issue
Primary Speed of Behaviour Reaction time in miliseconds 0-60 minutes after stimulation
Primary Accuracy of Behaviour Accuracy in percent correct 0-60 minutes after stimulation
Primary Cognitive Function driving Behaviour Parameter of Model describing cognitive function governing behaviour 0-60 minutes after stimulation
Primary Brain activity BOLD contrast in fMRI data 0-60 minutes after stimulation
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