Bed Rest Clinical Trial
Official title:
Preserving Muscle Mass and Function in Bedridden Older Adults
The investigators propose that low-intensity exercise and supplementing daily meals with leucine or whey will independently and synergistically reduce the deleterious effects of inactivity on skeletal muscle and facilitate recovery during rehabilitation.
The loss of muscle mass and function in older adults during bed rest is facilitated by
defects in the regulation of muscle protein metabolism, including an impaired ability to
mount an anabolic response to a mixed nutrient meal. The investigators propose that
low-intensity exercise and supplementing daily meals with leucine or whey will independently
and synergistically reduce the deleterious effects of inactivity on skeletal muscle and
facilitate recovery during rehabilitation. Metabolic measures will include: a) nutrient and
exercise-specific markers of translation initiation; b) skeletal muscle protein synthesis;
and c) a novel breath test of glucose tolerance. Morphologic and functional measures will
include: a) muscle mass and body composition; b) muscle strength and function; and c) motor
activation. The investigators will test the following hypotheses in older men and women
(65-80 years) during 7 days of bed rest followed by 7 days of inpatient rehabilitation:
1. Inactivity-induced metabolic dysregulation will blunt the anabolic response to meals,
facilitating a loss of lean muscle mass, glucose tolerance and functional capacity that
is partially restored during rehabilitation.
2. Supplementing daily meals with leucine or whey will maintain nutrient-stimulated
translation initiation and preserve the anabolic response to meal ingestion. This will
partially preserve lean muscle mass and function during bed rest and facilitate the
recovery of functional and metabolic capacity during rehabilitation.
3. Daily low-intensity exercise will preserve motor unit activation, stimulate the
exercise-regulated signaling pathway and normalize the anabolic response to meal
ingestion. This will partially preserve glucose tolerance, lean muscle mass and function
during bed rest and facilitate rehabilitation.
This translational project will provide mechanistic and practical insight into strategies to
reduce the negative consequences of physical inactivity and promote rehabilitation in aging
muscle. Our novel, minimally invasive and clinically interventions have direct application
for older hospitalized patients at risk of accelerated muscle loss and diminished functional
capacity.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03087643 -
Passive Mobilization and Vascular Function
|
N/A |