Topical Itraconazole in the Treatment of Basal Cell Carcinoma

Status Completed

Clinical Trial Summary

This research is being done to study the molecular effects of topically applied itraconazole ointment on the growth of basal cell carcinomas.

Clinical Trial Description

Basal cell carcinoma is the most common type of skin cancer in Caucasians worldwide. Although rarely metastatic, it can be locally destructive causing disfigurement and pain. Current therapies include surgical removal, local destruction, radiotherapy and others. Advances in understanding the molecular basis behind BCCs indicate that mutations in the hedgehog signaling pathway can lead to the development of many sporadically occurring basal cell carcinomas (BCCs). An oral drug that targets the hedgehog signaling pathway has been shown to be effective in treating patients with metastatic and inoperable BCCs. There is evidence that itraconazole, a commonly prescribed antifungal medication may also affect this pathway. It is not known whether itraconazole ointment applied topically can affect the growth of BCCs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02120677
Study type	Interventional
Source	Johns Hopkins University
Contact
Status	Completed
Phase	Early Phase 1
Start date	May 2014
Completion date	January 30, 2019

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