Barrett's Esophagus Clinical Trial
Official title:
Population Based Screening for Barrett's Esophagus in Olmsted County : A Pilot Study
To compare participation rates in screening for Barrett's Esophagus (BE) using sedated
esophagogastroduodenoscopy (EGD), unsedated transnasal endoscopy and capsule endoscopy in a
population based cohort. An age and gender stratified random sample of 300 patients from a
previously defined (in terms of the presence or absence of symptoms of gastroesophageal
reflux using a validated questionnaire) population based cohort from Olmsted County11, 12
using the Rochester Epidemiology Project (REP), who have not undergone endoscopy, will be
randomized to undergo screening using capsule endoscopy OR transnasal endoscopy OR
conventional sedated endoscopy. The investigators will compare participation rates in the
three arms.
To identify factors associated with non-participation in population screening for BE. The
investigators will compare demographic and clinical factors in participants and
non-participants, to help predict non-participation using data from prior surveys (data has
been collected on patient demographics, bowel and reflux symptoms, employment, education,
somatization behavior, psychological profiles using the validated Gastroesophageal Reflux
questionnaire [GERQ] and the Bowel Disease Questionnaire [BDQ]) which have been completed by
all targeted subjects. This preliminary will allow us to identify barriers to screening and
develop interventions to increase participation in future larger studies.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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