Familial Aggregation of Barrett's Esophagus

Barrett's Esophagus Clinical Trial

Official title:

Familial Aggregation of Barrett's Esophagus

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT00058877
• Other study ID #: FABE
• Status: Active, not recruiting
• Phase: N/A
• First received: April 14, 2003
• Last updated: March 17, 2010

Study information

• Verified date: March 2010
• Source: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

This research study is trying to determine whether Barrett's esophagus and associated esophageal cancers, specifically esophageal adenocarcinoma are inherited in certain families. Persons who are affected with Barrett's esophagus or esophageal cancer (adenocarcinoma type) are asked to complete a questionnaire that determines their habits and asks a detailed family history. Family members of patients seen at University Hospitals of Cleveland are also being recruited for screening tests of their esophagus. The investigators plan to eventually screen family members at all participating institutions. This research will eventually lead to the identification of inherited genetic changes that cause Barrett's esophagus and esophageal cancer. It will help the investigators develop better methods for preventing or identifying esophageal cancer at an early curable stage.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 650
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: N/A and older

Eligibility

Eligible cases will be defined as those patients and their family members who meet the following criteria:

• Barrett's esophagus confirmed by review of pathology and endoscopy report or adenocarcinoma of the esophagus or family members of person with Barrett's esophagus or adenocarcinoma of the esophagus.

• Male or female age 18 or older at time of enrollment or male or female less than 18 years of age at time of enrollment with parental consent.

• Ability to give informed consent, if patient is age 18 or older.

• No history of radiation to the chest or abdomen.

• No history of chemotherapy in the year preceding the initial diagnosis of Barrett's esophagus or esophageal adenocarcinoma.

Study Design

N/A

Related Conditions & MeSH terms

• Barrett Esophagus
• Barrett's Esophagus
• Esophageal Neoplasm
• Esophageal Neoplasms

Locations

Country	Name	City	State
United States	Cleveland Clinic Foundation	Cleveland	Ohio
United States	University Hospitals of Cleveland	Cleveland	Ohio
United States	Ohio State University	Columbus	Ohio
United States	Vanderbilt University Medical Center	Nashville	Tennessee

Sponsors (1)

Lead Sponsor	Collaborator
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Country where clinical trial is conducted

United States,