Longitudinal Oral Microbiome Sampling for BE

Status Recruiting

Clinical Trial Summary

This is a longitudinal cohort study to assess the impact of repeated sampling of an oral microbiome signature for Barrett's esophagus (BE). Potential participants will be identified through chart review of patients who have had an endoscopy in the past three years.

Clinical Trial Description

Saliva collection is non-invasive and can be performed in clinical and non-clinical settings. As such, saliva testing is a highly attractive method for diagnosing and/or monitoring disease. The investigators previously showed that the bacterial make-up ("microbiome") of saliva is highly distinct in patients with and without Barrett's esophagus (BE), a precursor to esophageal cancer that normally can only be diagnosed by undergoing an upper endoscopy. While the microbiome of saliva is felt to be relatively stable over time, it is unclear whether a microbiome signature for Barrett's esophagus is reproducible within individuals. Also, repeated testing of saliva may improve the ability to diagnose Barrett's esophagus. ;

Study Design

Related Conditions & MeSH terms

Barrett Esophagus

Clinical Trial Details

NCT number	NCT05133102
Study type	Observational
Source	Columbia University
Contact	Julian Abrams, MD
Phone	212-305-1909
Email	ja660@cumc.columbia.edu
Status	Recruiting
Phase
Start date	March 19, 2021
Completion date	August 2025

View Details

See also
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