Early Detection of Barrett's Esophagus Through Deep Image Retrieval

Barrett Esophagus Clinical Trial

Official title:

Early Detection of Cancer in Cases of Barrett's Esophagus Using Robotic Endoscopy Image Analysis Through Deep Image Retrieval

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT04478929
• Other study ID #: REDM0227_RP01
• Status: Not yet recruiting
• Start date: August 2020
• Est. completion date: August 2021

Study information

• Verified date: July 2020
• Source: University of the West of England
• Contact: Lyndon Winstone, PhD
• Phone: +4411732 82009
• Email: Lyndon.Smith[@]uwe.ac.uk
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Barrett's oesophagus is a condition in which the area between the oesophagus and stomach no longer closes, allowing acidic contents of the stomach to enter the oesophagus and damage the lining. The project aims to assist clinicians by offering informed biopsy process, in which the system presents the operator with clinical outcomes of patients with visually similar GI tracts. The project goal is to assess the use of artificial intelligence-based similarity detection systems to better inform biopsy placement, increasing the reliability of bi-yearly inspections.

Description:

The project intention is to acquire secondary endoscopy captured data from clinicians to create a sufficient dataset to train a learning system to achieve the stated objective. The data required will feature footage (images/videos) from inside the oesophagus. The preferred data would contain associated diagnosis notes and description, however, data without diagnosis can still be used. All data can and will be anonymised, as personal information will not be useful in this work.

The data will be labelled by either researchers, or professional clinicians and prepared ready to feed into a chosen learning AI system. Through an iterative learning process, the chosen AI system will learn to discriminate between severity of Barrett's oesophagus and output optimal biopsy target.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 300
• Est. completion date: August 2021
• Est. primary completion date: June 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult

• Attending Southmead Hospital for on OGD

• Has capacity

• Initially any indication, later patients with known Barrett's oesophagus

Exclusion Criteria:

• Children (<18)

• Patients without capacity

• Urgent and emergency procedures

• Limited English

Related Conditions & MeSH terms

• Barrett Esophagus

Intervention

Diagnostic Test:
• Gastroscopy
Routine gastroscopy

Locations

Country	Name	City	State
United Kingdom	NBT, Southmead Hospital	Bristol	Avon

Sponsors (2)

Lead Sponsor	Collaborator
Leigh Taylor	Cancer Research UK

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	gastroscopy image data set	Images collected during routine gastroscopy with examination notes	12 months