Barrett Esophagus Clinical Trial
Official title:
Endoscopic Submucosal Dissection for the Treatment of Early Barrett's Neoplasia
This study assesses the quality of the resection of early neoplasia arinsing in Barrett's esophagus using endoscopic submucosal dissection. It is a multicenter prospective registry among 7 centers including all consecutive patients with early Barrett's neoplasia of 15 mm or more in size treated by endoscopic submucosal dissection.
Endoscopic submucosal dissection ( ESD) demonstrated great efficacy in the treatment of
squamous cell carcinoma of the esophagus. Results for the treatment of esophageal
adenocarcinoma arising in Barrett's esophagus are conflicting.
In this multicenter prospective registry among 7 French centers, all consecutive patients
with early Barrett's neoplasia of 15 mm or more in size treated by endoscopic submucosal
dissection will be included in the registry. The primary objective is to assess the quality
of the resection by ESD of early Barrett's neoplasia (T1A or T1B sm1 or high grade
dysplasia). Secondary endpoints are to assess the combined efficacy of a treatment
associating ESD and radiofrequency ablation of the remaining Barrett esophagus, and to assess
the durability of the results after 3 years.
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